325601: Kawaguchi Makoto/Hara Noboru/Bilim Vladimir/Koike Hiroshi/Suzuki Mituko/Kim Tae-Sun/Gao Nan/Dong Yu/Zhang Sheng/Fujinawa Yuji/Yamamoto Osamu/Ito Hiromi/Tomita Yoshihiko/Naruse Yuchi/Sakamaki Akira/Ishii Yoko/[常山幸一]/Inoue Masaaki/Itoh Johbu/Yasuda Masanori/Sakata Nobuo/Jung Cha-Gyun/Kanazawa Satoshi/Akatsu Hiroyasu/Minato Hiroshi/Nojima Takayuki/Asai Kiyofumi/Miura Yutaka/A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression./[BMC Cancer]

著作: Kawaguchi Makoto/Hara Noboru/Bilim Vladimir/Koike Hiroshi/Suzuki Mituko/Kim Tae-Sun/Gao Nan/Dong Yu/Zhang Sheng/Fujinawa Yuji/Yamamoto Osamu/Ito Hiromi/Tomita Yoshihiko/Naruse Yuchi/Sakamaki Akira/Ishii Yoko/[常山幸一]/Inoue Masaaki/Itoh Johbu/Yasuda Masanori/Sakata Nobuo/Jung Cha-Gyun/Kanazawa Satoshi/Akatsu Hiroyasu/Minato Hiroshi/Nojima Takayuki/Asai Kiyofumi/Miura Yutaka/A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression./[BMC Cancer]

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EID: 325601
EOID: 874406
Map: 0
LastModified: 2017年10月26日(木) 17:25:21
Operator: 常山幸一
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種別

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学術論文(審査論文)

言語

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英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

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(英) Kawaguchi Makoto

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学籍番号推奨
(英) Hara Noboru

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(英) Bilim Vladimir

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(英) Koike Hiroshi

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学籍番号推奨
(英) Suzuki Mituko

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(英) Kim Tae-Sun

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(英) Gao Nan

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(英) Dong Yu

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(英) Zhang Sheng

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学籍番号推奨
(英) Fujinawa Yuji

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(英) Yamamoto Osamu

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(英) Ito Hiromi

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(英) Tomita Yoshihiko

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(英) Naruse Yuchi

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(英) Sakamaki Akira

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(英) Ishii Yoko

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常山幸一([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])

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(英) Inoue Masaaki

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(英) Itoh Johbu

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(英) Yasuda Masanori

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(英) Sakata Nobuo

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(英) Jung Cha-Gyun

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(英) Kanazawa Satoshi

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(英) Akatsu Hiroyasu

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(英) Minato Hiroshi

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(英) Nojima Takayuki

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(英) Asai Kiyofumi

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(英) Miura Yutaka

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題名

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(英) A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression.

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(英) Pathological stage and grade have limited ability to predict the outcomes of superficial urothelial bladder carcinoma at initial transurethral resection (TUR). AT-motif binding factor 1 (ATBF1) is a tumor suppressive transcription factor that is normally localized to the nucleus but has been detected in the cytoplasm in several cancers. Here, we examined the diagnostic value of the intracellular localization of ATBF1 as a marker for the identification of high risk urothelial bladder carcinoma. Seven anti-ATBF1 antibodies were generated to cover the entire ATBF1 sequence. Four human influenza hemagglutinin-derived amino acid sequence-tagged expression vectors with truncated ATBF1 cDNA were constructed to map the functional domains of nuclear localization signals (NLSs) with the consensus sequence KR[X10-12]K. A total of 117 samples from initial TUR of human bladder carcinomas were analyzed. None of the patients had received chemotherapy or radiotherapy before pathological evaluation. ATBF1 nuclear localization was regulated synergistically by three NLSs on ATBF1. The cytoplasmic fragments of ATBF1 lacked NLSs. Patients were divided into two groups according to positive nuclear staining of ATBF1, and significant differences in overall survival (P .021) and intravesical recurrence-free survival (P .013) were detected between ATBF1+ (n 10) and ATBF1- (n ) cases. Multivariate analysis revealed that ATBF1 staining was an independent prognostic factor for intravesical recurrence-free survival after adjusting for cellular grading and pathological staging (P .008). Cleavage of ATBF1 leads to the cytoplasmic localization of ATBF1 fragments and downregulates nuclear ATBF1. Alterations in the subcellular localization of ATBF1 due to fragmentation of the protein are related to the malignant character of urothelial carcinoma. Pathological evaluation using anti-ATBF1 antibodies enabled the identification of highly malignant cases that had been overlooked at initial TUR. Nuclear localization of ATBF1 indicates better prognosis of urothelial carcinoma.

キーワード

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発行所

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誌名

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BMC Cancer([BioMed Central Ltd.])

(eISSN: 1471-2407)

ISSN	任意	1471-2407 ISSN: 1471-2407 (eISSN: 1471-2407) Title: BMC cancer Title(ISO): BMC Cancer Publisher: BioMed Central (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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805 805

都市

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年月日

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2016年 10月 18日

URL

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DOI

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10.1186/s12885-016-2845-5 (→Scopusで検索)

PMID

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27756245 (→Scopusで検索)

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Scopus

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備考

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(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) KeywordList.Keyword: ATBF1
(英) KeywordList.Keyword: nuclear localization signals
(英) KeywordList.Keyword: prognostic marker
(英) KeywordList.Keyword: urothelial bladder carcinoma

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