徳島大学 教育・研究者情報データベース(EDB)

1. 曽我部 正弘([徳島大学.キャンパスライフ健康支援センター])

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. 岡久 稔也([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域総合医療学]/[徳島大学.病院.診療科.内科.消化器内科])

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. (英) Nakasono Masahiko

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. (英) Fukuno Hiroshi

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) Miyamoto Yoshihiko

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. (英) Okada Yasuyuki

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. (英) Okazaki Jun

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 三好 人正

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. 友成 哲

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. 谷口 達哉

    役割	任意
    貢献度	任意
    学籍番号	推奨

11. 郷司 敬洋

    役割	任意
    貢献度	任意
    学籍番号	推奨

12. 北村 晋志

    役割	任意
    貢献度	任意
    学籍番号	推奨

13. 宮本 弘志([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])

    役割	任意
    貢献度	任意
    学籍番号	推奨

14. 六車 直樹

    役割	任意
    貢献度	任意
    学籍番号	推奨

15. 高山 哲治([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) The differing influence of several factors on the development of fatty liver with elevation of liver enzymes between genders with metabolic syndrome: A cross-sectional study.

(英) Nonalcoholic fatty liver disease (NAFLD) is known to be strongly associated with obesity, visceral fat, metabolic syndrome (MS), lifestyle, and lifestyle-related diseases in both males and females. However, the prevalence of NAFLD, MS, and clinical backgrounds is different between males and females. We conducted a cross-sectional study to examine the differing influence of lifestyle-related factors and visceral fat on fatty liver (FL) with elevation of liver enzymes between males and females with MS. We enrolled 42,134 persons who underwent a regular health check-up, and after excluding subjects who fulfilled excluding criteria, the remaining subjects were 2,110 persons with MS. We examined the differing influence of lifestyle-related factors and visceral fat on FL with elevation of alanine aminotransferase (ALT) (ALT elevation was defined as ALT level of ≥31 IU/l in the present study). The odds rations for FL with ALT elevation were as follows: WC, 1.83 (95% confidence interval (CI) 1.36-2.46); dyslipidemia, 1.89 (95% CI 1.34-2.68); hemoglobin A1c, 1.36 (95% CI 1.00-1.85); visceral fat type MS (V-type MS), 5.78 (95% CI 4.29-7.80); and light drinker, 0.56 (95% CI 0.41-0.78) in males with MS and BMI, 2.18 (95% CI 1.43-3.33); WC, 1.85 (95% CI 1.27-2.70); diastolic blood pressure, 1.69 (95% CI 1.16-2.45); triglyceride, 2.22 (95% CI 1.56-3.17); impaired glucose tolerance, 1.66 (95% CI 1.11-2.47); and V-type MS, 3.83 (95% CI 2.57-5.70) in females with MS. The prevalence of FL with ALT elevation and ALT was significantly higher in V-type MS than in the subcutaneous fat type MS in both males and females with MS (P < 0.001). Although V-type MS and WC is a common significant predictor of an increased prevalence of FL with ALT elevation in both males and females with MS, gender, lifestyle-related factors, and MS type in individuals with MS should be considered for the development of FL with ALT elevation.

1. (英) Article.ELocationID: 10.1371/journal.pone.0177925

2. (英) Article.PublicationTypeList.PublicationType: Journal Article