徳島大学 教育・研究者情報データベース(EDB)

1. 細川 義隆([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])

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2. 細川 育子([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学])

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3. (英) Shindo Satoru / (日) 進藤 智

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4. (英) Ohta Yoshihiro / (日) 大田 佳宏

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5. 尾崎 和美([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])

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6. 松尾 敬志

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(英) Alkannin inhibits CCL3 and CCL5 production in human periodontal ligament cells.

(英) Alkannin, which is found in Alkanna tinctoria, a member of the borage family, is used as a food coloring. Alkannin has recently been reported to have certain biological functions, such as anti-microbial and anti-oxidant effects. It is known that CC chemokine receptor (CCR) 5-positive leukocytes contribute to alveolar bone resorption in periodontal lesions. The aim of this study was to examine whether alkannin inhibits the production of CC chemokine ligand (CCL) 3 and CCL5, which are CCR5 ligands, in human periodontal ligament cells (HPDLC). Interleukin (IL)-1 induced CCL3 and CCL5 production in HPDLC. Alkannin inhibited IL-1-mediated CCL3 and CCL5 production in HPDLC in a dose-dependent manner. Moreover, we revealed that alkannin suppressed inhibitor of kappa B- degradation in IL-1-stimulated HPDLC. In addition, a nuclear factor (NF)-B inhibitor significantly inhibited CCL3 and CCL5 production in IL-1-stimulated HPDLC. These results demonstrate that alkannin inhibits CCR5 ligand production in IL-1-stimulated HPDLC by attenuating the NF-B signaling pathway.

1. (英) Cells, Cultured
2. (英) Chemokine CCL3
3. (英) Chemokine CCL5
4. (英) Humans
5. (英) I-kappa B Proteins
6. (英) Interleukin-1beta
7. (英) Ligands
8. (英) Naphthoquinones
9. (英) Periodontal Ligament
10. リン酸化(phosphorylation)
11. (英) Proteolysis
12. (英) Transcription Factor RelA

1. (英) PublicationType: Journal Article