323883: Sasakabe Tae/Wakai Kenji/Kawai Sayo/Hishida Asahi/Naito Mariko/Suzuki Sadao/Nindita Yora/[有澤孝吉]/Kita Yoshikuni/Hara Megumi/Kuriyama Nagato/Hirata Akie/Mikami Haruo/Oze Isao/Kubo Michiaki/Tanaka Hideo/Hamajima Nobuyuki/Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men/[Journal of Epidemiology]

著作: Sasakabe Tae/Wakai Kenji/Kawai Sayo/Hishida Asahi/Naito Mariko/Suzuki Sadao/Nindita Yora/[有澤孝吉]/Kita Yoshikuni/Hara Megumi/Kuriyama Nagato/Hirata Akie/Mikami Haruo/Oze Isao/Kubo Michiaki/Tanaka Hideo/Hamajima Nobuyuki/Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men/[Journal of Epidemiology]

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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

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審査

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Peer Review

カテゴリ

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研究

共著種別

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国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))

学究種別

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組織

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著者

必須

(英) Sasakabe Tae

役割任意

貢献度任意

学籍番号推奨
(英) Wakai Kenji

役割任意

貢献度任意

学籍番号推奨
(英) Kawai Sayo

役割任意

貢献度任意

学籍番号推奨
(英) Hishida Asahi

役割任意

貢献度任意

学籍番号推奨
(英) Naito Mariko

役割任意

貢献度任意

学籍番号推奨
(英) Suzuki Sadao

役割任意

貢献度任意

学籍番号推奨
(英) Nindita Yora

役割任意

貢献度任意

学籍番号推奨
有澤孝吉

役割任意

貢献度任意

学籍番号推奨
(英) Kita Yoshikuni

役割任意

貢献度任意

学籍番号推奨
(英) Hara Megumi

役割任意

貢献度任意

学籍番号推奨
(英) Kuriyama Nagato

役割任意

貢献度任意

学籍番号推奨
(英) Hirata Akie

役割任意

貢献度任意

学籍番号推奨
(英) Mikami Haruo

役割任意

貢献度任意

学籍番号推奨
(英) Oze Isao

役割任意

貢献度任意

学籍番号推奨
(英) Kubo Michiaki

役割任意

貢献度任意

学籍番号推奨
(英) Tanaka Hideo

役割任意

貢献度任意

学籍番号推奨
(英) Hamajima Nobuyuki

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men

副題

任意

要約

任意

(英) Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was -2.49 mg/dL (95% confidence interval [CI], -3.85 to -1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated. The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.

キーワード

推奨

(英) Adult
(英) Aged
(英) Alcohol Dehydrogenase
(英) Alcohol Drinking
(英) Aldehyde Dehydrogenase, Mitochondrial
(英) Alleles
(英) Cohort Studies
(英) Genotype
(英) Humans
(英) Japan
(英) Lipoproteins, LDL
(英) Male
(英) Middle Aged
(英) Polymorphism, Genetic
(英) Triglycerides

発行所

推奨

誌名

必須

Journal of Epidemiology(日本疫学会)

(pISSN: 0917-5040, eISSN: 1349-9092)

ISSN	任意	1349-9092 ISSN: 0917-5040 (pISSN: 0917-5040, eISSN: 1349-9092) Title: Journal of epidemiology Title(ISO): J Epidemiol Supplier: 日本疫学会 Publisher: Elsevier B.V. (NLM Catalog) (医中誌Web) (J-STAGE) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

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頁

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185 193

都市

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年月日

必須

2017年 4月 5日

URL

任意

DOI

任意

10.2188/jea.JE20160189 (→Scopusで検索)

PMID

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29176272 (→Scopusで検索)

CRID

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WOS

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Scopus

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評価値

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被引用数

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指導教員

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備考

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(英) Article.ELocationID: 10.2188/jea.JE20160189
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) KeywordList.Keyword: ADH1B
(英) KeywordList.Keyword: ALDH2
(英) KeywordList.Keyword: alcohol intake
(英) KeywordList.Keyword: lipid profile

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