徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面形態学(2004年4月1日〜)

1. 篠原 丈裕([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. 井澤 俊

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. 三野 彰子([徳島大学.口腔科学研究科.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. 森 浩喜

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. 岩浅 亮彦

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. 犬伏 俊博([広島大学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. (英) Yamaguchi Yu

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 田中 栄二([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Hyaluronan metabolism in overloaded temporomandibular joint

(英) This study aimed to examine hyaluronan (HA) metabolism in relation to the onset and progression of temporomandibular joint osteoarthritis (TMJ-OA) induced by mechanical overloading. Two-month-old and 6-month-old C57BL/6N mice were divided into experimental and untreated control groups (n = 5/group). A sliding plate was attached to the maxillary incisors of the experimental mice for 10 days to overload the condylar cartilage in TMJ. In experimental group, profound cartilage degradation was detected in haematoxylin-eosin, Safranin-O-Fast Green-stained sections. It was also shown that the cartilage degradation was greater in older mice in both the control and the experimental groups. The number of HABP-positive cells was decreased by mechanical overloading and with age. The reduction of HA expression was correlated with the progression of cartilage degradation induced by mechanical overloading. The absolute quantification of the mRNA expression related to HA synthesis and HA degradation was also performed in each group. The mRNA expression levels of HA synthase (HAS) 2 and 3 were lower in the experimental group compared with the control group in the younger mice. In contrast, the mRNA expression levels of the HA degradation gene, HYAL2 and KIAA1199, were higher in the experimental group compared with the control group in the older mice. Thus, mechanical overload differently affected the balance of HA degradation and HA synthesis in the older and younger mice, respectively. In conclusion, mechanical overloading affects HA metabolism and it might initiate or amplify the condylar cartilage degradation.

1. (英) Article.ELocationID: 10.1111/joor.12443

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) KeywordList.Keyword: hyaluronan

4. (英) KeywordList.Keyword: osteoarthritis

5. (英) KeywordList.Keyword: temporomandibular joint