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著作: Tamaki Masanori/Hagiwara Aika/Miyashita Kazutoshi/Wakino Shu/Inoue Hiroyuki/Fujii Kentaro/Fujii Chikako/Sato Masaaki/Mitsuishi Masanori/Muraki Ayako/Hayashi Koichi/[土井 俊夫]/Itoh Hiroshi/Improvement of Physical Decline Through Combined Effects of Muscle Enhancement and Mitochondrial Activation by a Gastric Hormone Ghrelin in Male 5/6Nx CKD Model Mice./[Endocrinology]

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EID
319967
EOID
834705
Map
0
LastModified
2016年9月1日(木) 14:54:59
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
土井 俊夫
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種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tamaki Masanori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Hagiwara Aika
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Miyashita Kazutoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Wakino Shu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Inoue Hiroyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Fujii Kentaro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Fujii Chikako
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Sato Masaaki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Mitsuishi Masanori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. (英) Muraki Ayako
    役割 任意
    貢献度 任意
    学籍番号 推奨
  11. (英) Hayashi Koichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  12. 土井 俊夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
  13. (英) Itoh Hiroshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Improvement of Physical Decline Through Combined Effects of Muscle Enhancement and Mitochondrial Activation by a Gastric Hormone Ghrelin in Male 5/6Nx CKD Model Mice.

副題 任意
要約 任意

(英) Because a physical decline correlates with an increased risk of a wide range of disease and morbidity, an improvement of physical performance is expected to bring significant clinical benefits. The primary cause of physical decline in 5/6 nephrectomized (5/6Nx) chronic kidney disease model mice has been regarded as a decrease in muscle mass; however, our recent study showed that a decrease in muscle mitochondria plays a critical role. In the present study, we examined the effects of a gastric hormone ghrelin, which has been reported to promote muscle mitochondrial oxidation, on the physical decline in the chronic kidney disease model mice, focusing on the epigenetic modulations of a mitochondrial activator gene, peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). Ghrelin treatment improved a decline in exercise endurance of 5/6Nx mice, associated with an increase in both of the muscle mass and mitochondrial amount. The expression level of PGC-1α was decreased in the skeletal muscle of 5/6Nx mice, which was associated with an increase in the methylation ratio of the cytosine residue at 260 base pairs upstream of the initiation point. Conversely, ghrelin treatment de-methylated the cytosine residue and increased the expression of PGC-1α. A representative muscle anabolic factor, IGF-1, did not affect the expression of PGC-1α and muscle mitochondrial amount, although it increased muscle mass. As a result, IGF-1 treatment in 5/6Nx mice did not increase the decreased exercise endurance as effectively as ghrelin treatment did. These findings indicate an advantage of ghrelin treatment for a recovery of physical decline.

キーワード 推奨
  1. (英) AMP-Activated Protein Kinases
  2. (英) Animals
  3. (英) Blotting, Western
  4. (英) Cell Line
  5. (英) DNA Methylation
  6. (英) Disease Models, Animal
  7. (英) Electron Transport Complex IV
  8. (英) Gene Expression
  9. (英) Ghrelin
  10. (英) Male
  11. (英) Mice, Inbred C57BL
  12. (英) Mitochondria, Muscle
  13. (英) Motor Activity
  14. (英) Muscle Weakness
  15. (英) Muscle, Skeletal
  16. (英) Myoblasts
  17. (英) Nephrectomy
  18. (英) RNA Interference
  19. (英) Receptors, Ghrelin
  20. (英) Renal Insufficiency, Chronic
  21. (英) Reverse Transcriptase Polymerase Chain Reaction
  22. (英) Transcription Factors
発行所 推奨
誌名 必須 Endocrinology([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)
ISSN 任意 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 156
必須 10
必須 3638 3648
都市 任意
年月日 必須 2015年 8月 4日
URL 任意
DOI 任意 10.1210/en.2015-1353    (→Scopusで検索)
PMID 任意 26241123    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1210/en.2015-1353

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't