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著作: [森田 恭二]/[後藤田 貴子]/[有持 秀喜]/Mi-Sook Lee/Song Her/Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells/[Journal of Neuroscience Research]

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EID
318919
EOID
856592
Map
0
LastModified
2017年6月10日(土) 18:36:59
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
有持 秀喜
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨 国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
学究種別 推奨
組織 推奨
著者 必須
  1. 森田 恭二
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 後藤田 貴子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 有持 秀喜([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Mi-Sook Lee
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Song Her
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells

副題 任意
要約 任意

(英) Progesterone treatment has previously been reported to promote the differentiation of glial cells probably through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated brain-derived neurotrophic factor (BDNF) gene expression, which is considered to contribute to the survival, regeneration, and plasticity of neuronal cells in the brain and hence has been suggested to improve mood disorders and other symptoms in depressive patients. Based on these previous observations, the effects on glial cells of histone deacetylase (HDAC) inhibitors, which are known as agents promoting cell differentiation, were examined using rat C6 glioma cells as a model for in vitro studies. Consequently, trichostatin A (TSA), sodium butyrate (NaB), and valproic acid (VPA) stimulated glial fibrillary acidic protein (GFAP) gene expression, and their stimulatory effects on GFAP gene expression were inhibited by treatment of these cells with finasteride, an inhibitor of the enzyme producing 5alpha-reduced neurosteroids. In addition, HDAC inhibitors enhanced serotonin-stimulated BDNF gene expression, the enhancement of which could be abolished by the inhibition of 5alpha-reduced neurosteroid production in the glioma cells. These results suggest that HDAC inhibitors may be able to promote the differentiation of rat C6 glioma cells through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated BDNF gene expression as a consequence of promoting their differentiation, indicating the possibility that differentiated glial cells may be implicated in preserving the integrity of neural networks as well as improving the function of neuronal cells in the brain.

キーワード 推奨
  1. (英) Animals
  2. (英) Brain-Derived Neurotrophic Factor
  3. (英) Butyrates
  4. (英) Cell Differentiation
    データベース中に適合する可能性のある以下の情報を発見しました
    [キーワード] 細胞増殖·分化 (cell proliferation and differentiation)
    [キーワード] 細胞分化 (cell differentiation)
  5. (英) Cell Line, Tumor
  6. (英) Dose-Response Relationship, Drug
  7. (英) Enzyme Inhibitors
  8. (英) Finasteride
  9. (英) Gene Expression
    データベース中に適合する可能性のある以下の情報を発見しました
    [キーワード] 遺伝子発現 (gene expression)
  10. (英) Glial Fibrillary Acidic Protein
  11. (英) Histone Deacetylase Inhibitors
  12. (英) Hydroxamic Acids
  13. (英) Neuroglia
  14. (英) RNA, Messenger
  15. (英) Rats
  16. (英) Serotonin
  17. (英) Sodium Compounds
  18. (英) Steroids
  19. (英) Time Factors
  20. (英) Valproic Acid
発行所 推奨
誌名 必須 Journal of Neuroscience Research(Wiley Interscience)
(pISSN: 0360-4012, eISSN: 1097-4547)
ISSN 任意 1097-4547
ISSN: 0360-4012 (pISSN: 0360-4012, eISSN: 1097-4547)
Title: Journal of neuroscience research
Title(ISO): J. Neurosci. Res.
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 87
必須 11
必須 2608 2614
都市 任意
年月日 必須 2009年 8月 15日
URL 任意
DOI 任意 10.1002/jnr.22072    (→Scopusで検索)
PMID 任意 19360904    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-70349234526
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1002/jnr.22072

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article