315723: Inaba, H/Goto, H/Kasahara, K/Kumamoto, K/[米村重信]/Inoko, A/Yamano, S/Wanibuchi, H/He, D/Goshima, N/Kiyono, T/Hirotsune, S/Inagaki, M/Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway./[The Journal of Cell Biology]

著作: Inaba, H/Goto, H/Kasahara, K/Kumamoto, K/[米村重信]/Inoko, A/Yamano, S/Wanibuchi, H/He, D/Goshima, N/Kiyono, T/Hirotsune, S/Inagaki, M/Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway./[The Journal of Cell Biology]

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EID: 315723
EOID: 841607
Map: 0
LastModified: 2016年12月9日(金) 11:38:49
Operator: 大家隆弘
Avail: TRUE
Censor: 承認済
Owner: 米村重信
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

著者

必須

(英) Inaba, H

役割任意

貢献度任意

学籍番号推奨
(英) Goto, H

役割任意

貢献度任意

学籍番号推奨
(英) Kasahara, K

役割任意

貢献度任意

学籍番号推奨
(英) Kumamoto, K

役割任意

貢献度任意

学籍番号推奨
米村重信([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])

役割任意

貢献度任意

学籍番号推奨
(英) Inoko, A

役割任意

貢献度任意

学籍番号推奨
(英) Yamano, S

役割任意

貢献度任意

学籍番号推奨
(英) Wanibuchi, H

役割任意

貢献度任意

学籍番号推奨
(英) He, D

役割任意

貢献度任意

学籍番号推奨
(英) Goshima, N

役割任意

貢献度任意

学籍番号推奨
(英) Kiyono, T

役割任意

貢献度任意

学籍番号推奨
(英) Hirotsune, S

役割任意

貢献度任意

学籍番号推奨
(英) Inagaki, M

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.

副題

任意

要約

任意

(英) Primary cilia protrude from the surface of quiescent cells and disassemble at cell cycle reentry. We previously showed that ciliary reassembly is suppressed by trichoplein-mediated Aurora A activation pathway in growing cells. Here, we report that Ndel1, a well-known modulator of dynein activity, localizes at the subdistal appendage of the mother centriole, which nucleates a primary cilium. In the presence of serum, Ndel1 depletion reduces trichoplein at the mother centriole and induces unscheduled primary cilia formation, which is reverted by forced trichoplein expression or coknockdown of KCTD17 (an E3 ligase component protein for trichoplein). Serum starvation induced transient Ndel1 degradation, subsequent to the disappearance of trichoplein at the mother centriole. Forced expression of Ndel1 suppressed trichoplein degradation and axonemal microtubule extension during ciliogenesis, similar to trichoplein induction or KCTD17 knockdown. Most importantly, the proportion of ciliated and quiescent cells was increased in the kidney tubular epithelia of newborn Ndel1-hypomorphic mice. Thus, Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.

キーワード

推奨

(英) Adaptor Proteins, Signal Transducing
(英) Animals
(英) Animals, Newborn
(英) Aurora Kinase A
(英) Carrier Proteins
(英) Cell Cycle Checkpoints
(英) Cell Proliferation
(英) Centrioles
(英) Cilia
(英) Epithelial Cells
(英) Genotype
(英) HeLa Cells
(英) Humans
(英) Kidney Tubules
(英) Mice
(英) Mice, Knockout
(英) Microtubules
(英) Phenotype
(英) Protein Stability
(英) Proteolysis
(英) RNA Interference
(英) Signal Transduction
(英) Swiss 3T3 Cells
(英) Time Factors
(英) Transfection

発行所

推奨

誌名

必須

The Journal of Cell Biology(Rockefeller Institute/American Society for Cell Biology)

(pISSN: 0021-9525, eISSN: 1540-8140)

ISSN	任意	1540-8140 ISSN: 0021-9525 (pISSN: 0021-9525, eISSN: 1540-8140) Title: The Journal of cell biology Title(ISO): J Cell Biol Publisher: Rockefeller University Press (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

212

号

必須

頁

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409 423

都市

任意

年月日

必須

2016年 2月 15日

URL

任意

DOI

任意

10.1083/jcb.201507046 (→Scopusで検索)

PMID

任意

26880200 (→Scopusで検索)

CRID

任意

WOS

任意

000370488700007

Scopus

任意

2-s2.0-84959468418

評価値

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被引用数

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指導教員

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備考

任意

(英) Article.ELocationID: 10.1083/jcb.201507046
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) OtherID: PMC4754717

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Inaba, H/Goto, H/Kasahara, K/Kumamoto, K/[米村重信]/Inoko, A/Yamano, S/Wanibuchi, H/He, D/Goshima, N/Kiyono, T/Hirotsune, S/Inagaki, M/Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway./[The Journal of Cell Biology]

著作: Inaba, H/Goto, H/Kasahara, K/Kumamoto, K/[米村 重信]/Inoko, A/Yamano, S/Wanibuchi, H/He, D/Goshima, N/Kiyono, T/Hirotsune, S/Inagaki, M/Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway./[The Journal of Cell Biology]

著作: Inaba, H/Goto, H/Kasahara, K/Kumamoto, K/[米村重信]/Inoko, A/Yamano, S/Wanibuchi, H/He, D/Goshima, N/Kiyono, T/Hirotsune, S/Inagaki, M/Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway./[The Journal of Cell Biology]