徳島大学 教育・研究者情報データベース(EDB)

1. 岩田 明子

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2. 三田村 佳典([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])

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3. (英) Niki Masanori

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4. 仙波 賢太郎([徳島大学.病院.中央診療施設等.周産母子センター])

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5. 江川 麻理子([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])

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6. 香留 崇

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7. (英) Sonoda Shozo

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8. (英) Sakamoto Taiji

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(英) Binarization of enhanced depth imaging optical coherence tomographic images of an eye with Wyburn-Mason syndrome: a case report.

(英) To report a thicker choroid and larger choroidal luminal area in an eye with Wyburn-Mason syndrome. To the best of our knowledge, this is the first report demonstrating an increase in the choroidal thickness and the luminal area in a case of Wyburn-Mason syndrome. In addition, we report the changing appearance of retinal arteriovenous malformations over a 16-year period. A 27-year-old woman, who was diagnosed with Wyburn-Mason syndrome at age 11 years, visited our clinic. Her best-corrected visual acuity was 20/12.5 in the right eye and light perception in the left eye. Severely dilated, tortuous vascular loops were distributed from the optic disc over all four quadrants of the left fundus. The vascular loops in some areas were more dilated and tortuous than 16 years earlier. Optical coherence tomography (OCT) showed retinal edema with cystic changes and enlarged choroidal vessel lumens in the left eye. The subfoveal choroidal thickness was manually measured by the caliper function in the enhanced depth imaging OCT (EDI-OCT) images. Binarization of the EDI-OCT images was performed with publicly accessible ImageJ software. The examined area of the subfoveal choroid was 1,500 m wide, and the dark areas representing the luminal areas were traced by the Niblack method. After determining the distance of each pixel, the luminal area was automatically calculated. The subfoveal choroidal thickness was 250 m in the right eye and 462 m in the left eye. The luminal area of the 1,500-m-wide subfoveal choroid was computed to be 307,165.6 m(2) in the right eye and 545,780.7 m(2) in the left eye. The EDI-OCT images showed a thicker choroid, and binarization of the EDI-OCT images showed that the luminal areas were significantly larger in the affected eye, suggesting a dilatation of the choroidal vessels. The results demonstrated that conversion of EDI-OCT images to binary images was a useful method to quantify the choroidal structure.

1. (英) Adult
2. (英) Arteriovenous Fistula
3. (英) Arteriovenous Malformations
4. (英) Choroid
5. (英) Choroid Diseases
6. (英) Female
7. (英) Fluorescein Angiography
8. (英) Humans
9. (英) Neurocutaneous Syndromes
10. (英) Organ Size
11. (英) Retinal Artery
12. (英) Retinal Vein
13. (英) Tomography, Optical Coherence
14. (英) Visual Acuity

1. (英) Article.ELocationID: 10.1186/s12886-015-0014-2

2. (英) Article.PublicationTypeList.PublicationType: Case Reports

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

5. (英) SupplMeshList.SupplMeshName: Wyburn Mason's syndrome

6. (英) OtherID: PMC4359503