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著作: [江川 麻理子]/[三田村 佳典]/Sano Hiroki/Akaiwa Kei/Niki Masanori/[仙波 賢太郎]/Sonoda Shozo/Sakamoto Taiji/Changes of choroidal structure after treatment for primary intraocular lymphoma: retrospective, observational case series./[BMC Ophthalmology]

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EID
315017
EOID
828557
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LastModified
2016年8月15日(月) 11:02:36
Operator
江川 麻理子
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Owner
三田村 佳典
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 江川 麻理子([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 三田村 佳典([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Sano Hiroki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Akaiwa Kei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Niki Masanori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 仙波 賢太郎([徳島大学.病院.中央診療施設等.周産母子センター])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Sonoda Shozo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Sakamoto Taiji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Changes of choroidal structure after treatment for primary intraocular lymphoma: retrospective, observational case series.

副題 任意
要約 任意

(英) We report changes of choroidal structure determined by binarization of enhanced depth imaging optical coherence tomographic (EDI-OCT) images after treatment for primary intraocular lymphoma (PIOL). Five eyes of four patients with PIOL were examined by EDI-OCT before and 6 months after intravitreal methotrexate injections. In addition, 15 eyes of 15 normal individuals controlled by age and refractive error were examined by EDI-OCT. Binarization of the EDI-OCT images was performed using publicly accessible software (ImageJ). The examined area of the subfoveal choroid was 1,500 m wide, and the dark areas that represented the luminal areas were traced by the Niblack method. Wilcoxon signed rank test was used to determine the significance of changes in the subfoveal choroidal thickness, interstitial area, and luminal area. Mann-Whitney U test was used to compare the parameters in the eyes with pretreatment PIOL and normal control eyes. The subfoveal choroidal thickness was significantly decreased after treatment (P = 0.0431). In the binarized images, the interstitial area was significantly decreased after treatment (P = 0.0431), while the luminal area was not significantly changed (P = 0.8927). After delayed onset of PIOL, increased interstitial area, thickened choroid and unchanged luminal area were observed in one eye. The interstitial area and choroidal thickness were significantly increased in the eyes with pretreatment PIOL compared with the normal control eyes (P = 0.0207, P = 0.0495, respectively), while the luminal area was not significantly different (P = 0.2752). After treatment for PIOL, the EDI-OCT images showed a thinner choroid, and binarization of the EDI-OCT images showed significantly decreased interstitial areas compared with the luminal areas. The binarized EDI-OCT images can provide useful information on choroidal structure in eyes with PIOL, and combining these images with intraocular interleukin levels or fundus autofluorescence images should provide valuable information for determining the PIOL activity.

キーワード 推奨
  1. (英) Aged
  2. (英) Antimetabolites, Antineoplastic
  3. (英) Choroid Diseases
  4. (英) Female
  5. (英) Humans
  6. (英) Intravitreal Injections
  7. (英) Lymphoma, Large B-Cell, Diffuse
  8. (英) Male
  9. (英) Methotrexate
  10. (英) Middle Aged
  11. (英) Retinal Neoplasms
  12. (英) Retrospective Studies
  13. (英) Tomography, Optical Coherence
発行所 推奨
誌名 必須 BMC Ophthalmology([BioMed Central Ltd.])
(eISSN: 1471-2415)
ISSN 任意 1471-2415
ISSN: 1471-2415 (eISSN: 1471-2415)
Title: BMC ophthalmology
Title(ISO): BMC Ophthalmol
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 15
必須
必須 136 136
都市 任意
年月日 必須 2015年 10月 19日
URL 任意
DOI 任意 10.1186/s12886-015-0127-7    (→Scopusで検索)
PMID 任意 26482033    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1186/s12886-015-0127-7

  2. (英) Article.PublicationTypeList.PublicationType: Case Reports

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Observational Study

  5. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  6. (英) OtherID: PMC4617452