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著作: Nagasato Daisuke/[三田村 佳典]/[仙波 賢太郎]/Akaiwa Kei/[長澤 利彦]/Yoshizumi Yuki/Tabuchi Hitoshi/Kiuchi Yoshiaki/Correlation between optic nerve head circulation and visual function before and after anti-VEGF therapy for central retinal vein occlusion: prospective, interventional case series./[BMC Ophthalmology]

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2017年12月12日(火) 14:04:37
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三木 ちひろ
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三田村 佳典
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Nagasato Daisuke
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 三田村 佳典([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 仙波 賢太郎([徳島大学.病院.中央診療施設等.周産母子センター])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Akaiwa Kei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 長澤 利彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Yoshizumi Yuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Tabuchi Hitoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Kiuchi Yoshiaki
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Correlation between optic nerve head circulation and visual function before and after anti-VEGF therapy for central retinal vein occlusion: prospective, interventional case series.

副題 任意
要約 任意

(英) To determine the correlation between the optic nerve head (ONH) circulation determined by laser speckle flowgraphy and the best-corrected visual acuity or retinal sensitivity before and after intravitreal bevacizumab or ranibizumab for central retinal vein occlusion. Thirty-one eyes of 31 patients were treated with intravitreal bevacizumab or ranibizumab for macular edema due to a central retinal vein occlusion. The blood flow in the large vessels on the ONH, the best-corrected visual acuity, and retinal sensitivity were measured at the baseline, and at 1, 3, and 6 months after treatment. The arteriovenous passage time on fluorescein angiography was determined. The venous tortuosity index was calculated on color fundus photograph by dividing the length of the tortuous retinal vein by the chord length of the same segment. The blood flow was represented by the mean blur rate (MBR) determined by laser speckle flowgraphy. To exclude the influence of systemic circulation and blood flow in the ONH tissue, the corrected MBR was calculated as MBR of ONH vessel area - MBR of ONH tissue area in the affected eye divided by the vascular MBR - tissue MBR in the unaffected eye. Pearson's correlation tests were used to determine the significance of correlations between the MBR and the best-corrected visual acuity, retinal sensitivity, arteriovenous passage time, or venous tortuosity index. At the baseline, the corrected MBR was significantly correlated with the arteriovenous passage time and venous tortuosity index (r = -0.807, P < 0.001; r = -0.716, P < 0.001; respectively). The corrected MBR was significantly correlated with the best-corrected visual acuity and retinal sensitivity at the baseline, and at 1, 3, and 6 months (all P < 0.050). The corrected MBR at the baseline was significantly correlated with the best-corrected visual acuity at 6 months (r = -0.651, P < 0.001) and retinal sensitivity at 6 months (r = 0.485, P = 0.005). The pre-treatment blood flow velocity of ONH can be used as a predictive factor for the best-corrected visual acuity and retinal sensitivity after anti-VEGF therapy for central retinal vein occlusion. UMIN000009072. Date of registration: 10/15/2012.

キーワード 推奨
  1. (英) Adult
  2. (英) Aged
  3. (英) Aged, 80 and over
  4. (英) Angiogenesis Inhibitors
  5. (英) Bevacizumab
  6. (英) Blood Circulation
  7. (英) Blood Flow Velocity
  8. (英) Female
  9. (英) Fluorescein Angiography
  10. (英) Humans
  11. (英) Intravitreal Injections
  12. (英) Laser-Doppler Flowmetry
  13. (英) Male
  14. (英) Middle Aged
  15. (英) Optic Disk
  16. (英) Prospective Studies
  17. (英) Ranibizumab
  18. (英) Retinal Vein Occlusion
  19. (英) Tomography, Optical Coherence
  20. (英) Vascular Endothelial Growth Factor A
  21. (英) Visual Acuity
  22. (英) Visual Field Tests
発行所 推奨
誌名 必須 BMC Ophthalmology([BioMed Central Ltd.])
(eISSN: 1471-2415)
ISSN 任意 1471-2415
ISSN: 1471-2415 (eISSN: 1471-2415)
Title: BMC ophthalmology
Title(ISO): BMC Ophthalmol
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 16
必須 ---
必須 36 36
都市 任意
年月日 必須 2016年 4月 5日
URL 任意
DOI 任意 10.1186/s12886-016-0211-7    (→Scopusで検索)
PMID 任意 27044276    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意 2-s2.0-85008195243
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1186/s12886-016-0211-7

  2. (英) Article.DataBankList.DataBank.DataBankName: JPRN

  3. (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: UMIN000009072

  4. (英) Article.PublicationTypeList.PublicationType: Journal Article

  5. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  6. (英) OtherID: PMC4820868

  7. (英) KeywordList.Keyword: Anti-vascular endothelial growth factor agent

  8. (英) KeywordList.Keyword: Central retinal vein occlusion

  9. (英) KeywordList.Keyword: Fundus-related microperimetry

  10. (英) KeywordList.Keyword: Laser speckle flowgraphy

  11. (英) KeywordList.Keyword: Retinal blood flow