徳島大学 教育・研究者情報データベース(EDB)

1. (英) Shindo Satoru / (日) 進藤 智 / (読) しんどう さとる

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2. 細川 義隆([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])

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3. 細川 育子([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学])

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4. 尾崎 和美([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])

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5. 松尾 敬志

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(英) Shikonin Inhibits Inflammatory Cytokine Production in Human Periodontal Ligament Cells.

(英) Shikonin, which is derived from Lithospermum erythrorhizon, a herb used in traditional medicine, has long been considered to be a useful treatment for various diseases in traditional oriental medicine. Shikonin has recently been reported to have several pharmacological properties, e.g., it has anti-microbial, anti-tumor, and anti-inflammatory effects. The aim of this study was to examine whether shikonin is able to influence the production of interleukin (IL)-6, IL-8, and/or chemokine C-C motif ligand (CCL)20, which contribute to the pathogenesis of periodontal disease, in human periodontal ligament cells (HPDLC). The production levels of IL-6, IL-8, and CCL20 in HPDLC were determined using an ELISA. Western blot analysis was used to detect nuclear factor kappa B (NF-B) pathway activation in HPDLC. Shikonin prevented IL-1- or tumor necrosis factor (TNF)--mediated IL-6, IL-8, and CCL20 production in HPDLC. Moreover, we found that shikonin suppressed the phosphorylation and degradation of inhibitor of kappa B-alpha (IB-) in IL-1- or TNF--stimulated HPDLC. These findings suggest that shikonin could have direct beneficial effects against periodontal disease by reducing IL-6, IL-8, and CCL20 production in periodontal lesions.

1. (英) PublicationType: Journal Article