313985: Oyama Jun-Ichi/Tanaka Atsushi/Sato Yasunori/Tomiyama Hirofumi/[佐田政隆]/Ishizu Tomoko/Taguchi Isao/Kuroyanagi Takanori/Teragawa Hiroki/Ishizaka Nobukazu/Kanzaki Yumiko/Ohishi Mitsuru/Eguchi Kazuo/Higashi Yukihito/[山田博胤]/Maemura Koji/Ako Junya/Bando K. Yasuko/Ueda Shinichiro/Inoue Teruo/Murohara Toyoaki/Node Koichi/Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study./[Cardiovascular Diabetology]

著作: Oyama Jun-Ichi/Tanaka Atsushi/Sato Yasunori/Tomiyama Hirofumi/[佐田政隆]/Ishizu Tomoko/Taguchi Isao/Kuroyanagi Takanori/Teragawa Hiroki/Ishizaka Nobukazu/Kanzaki Yumiko/Ohishi Mitsuru/Eguchi Kazuo/Higashi Yukihito/[山田博胤]/Maemura Koji/Ako Junya/Bando K. Yasuko/Ueda Shinichiro/Inoue Teruo/Murohara Toyoaki/Node Koichi/Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study./[Cardiovascular Diabetology]

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EID: 313985
EOID: 840443
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LastModified: 2016年11月25日(金) 14:58:43
Operator: 三木ちひろ
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Owner: 佐田政隆
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

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共著種別

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国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))

学究種別

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組織

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著者

必須

(英) Oyama Jun-Ichi

役割任意

貢献度任意

学籍番号推奨
(英) Tanaka Atsushi

役割任意

貢献度任意

学籍番号推奨
(英) Sato Yasunori

役割任意

貢献度任意

学籍番号推奨
(英) Tomiyama Hirofumi

役割任意

貢献度任意

学籍番号推奨
佐田政隆([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])

役割任意

貢献度任意

学籍番号推奨
(英) Ishizu Tomoko

役割任意

貢献度任意

学籍番号推奨
(英) Taguchi Isao

役割任意

貢献度任意

学籍番号推奨
(英) Kuroyanagi Takanori

役割任意

貢献度任意

学籍番号推奨
(英) Teragawa Hiroki

役割任意

貢献度任意

学籍番号推奨
(英) Ishizaka Nobukazu

役割任意

貢献度任意

学籍番号推奨
(英) Kanzaki Yumiko

役割任意

貢献度任意

学籍番号推奨
(英) Ohishi Mitsuru

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貢献度任意

学籍番号推奨
(英) Eguchi Kazuo

役割任意

貢献度任意

学籍番号推奨
(英) Higashi Yukihito

役割任意

貢献度任意

学籍番号推奨
山田博胤([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])

役割任意

貢献度任意

学籍番号推奨
(英) Maemura Koji

役割任意

貢献度任意

学籍番号推奨
(英) Ako Junya

役割任意

貢献度任意

学籍番号推奨
(英) Bando K. Yasuko

役割任意

貢献度任意

学籍番号推奨
(英) Ueda Shinichiro

役割任意

貢献度任意

学籍番号推奨
(英) Inoue Teruo

役割任意

貢献度任意

学籍番号推奨
(英) Murohara Toyoaki

役割任意

貢献度任意

学籍番号推奨
(英) Node Koichi

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study.

副題

任意

要約

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(英) BACKGROUND: Xanthine oxidase inhibitors are anti-hyperuricemic drugs that decrease serum uric acid levels by inhibiting its synthesis. Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative stress. Excess oxidative stress induces endothelial dysfunction and inflammatory reactions in vascular systems, leading to atherosclerosis. Many experimental studies have suggested that xanthine oxidase inhibitors have anti-atherosclerotic effects by decreasing in vitro and in vivo oxidative stress. However, there is only limited evidence on the clinical implications of xanthine oxidase inhibitors on atherosclerotic cardiovascular disease in patients with hyperuricemia. We designed the PRIZE study to evaluate the effects of febuxostat on a surrogate marker of cardiovascular disease risk, ultrasonography-based intima-media thickness of the carotid artery in patients with hyperuricemia.METHODS: The study is a multicenter, prospective, randomized, open-label and blinded-endpoint evaluation (PROBE) design. A total of 500 patients with asymptomatic hyperuricemia (uric acid >7.0 mg/dL) and carotid intima-media thickness 1.1 mm will be randomized centrally to receive either febuxostat (10-60 mg/day) or non-pharmacological treatment. Randomization is carried out using the dynamic allocation method stratified according to age (<65, 65 year), gender, presence or absence of diabetes mellitus, serum uric acid (<8.0, 8.0 mg/dL), and carotid intima-media thickness (<1.3, 1.3 mm). In addition to administering the study drug, we will also direct lifestyle modification in all participants, including advice on control of body weight, sleep, exercise and healthy diet. Carotid intima-media thickness will be evaluated using ultrasonography performed by skilled technicians at a central laboratory. Follow-up will be continued for 24 months. The primary endpoint is percentage change in mean intima-media thickness of the common carotid artery 24 months after baseline, measured by carotid ultrasound imaging.CONCLUSIONS: PRIZE will be the first study to provide important data on the effects of febuxostat on atherosclerosis in patients with asymptomatic hyperuricemia. Trial Registration Unique trial Number, UMIN000012911 ( https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000015081&language=E ).

キーワード

推奨

頸動脈(carotid artery)
(英) Febuxostat
(英) Hyperuricemia
(英) Intima-media thickness (IMT)
(英) Xanthine oxidase inhibitor

発行所

推奨

BioMed Central Ltd.

誌名

必須

Cardiovascular Diabetology([BioMed Central Ltd.])

(eISSN: 1475-2840)

ISSN	任意	1475-2840 ISSN: 1475-2840 (eISSN: 1475-2840) Title: Cardiovascular diabetology Title(ISO): Cardiovasc Diabetol Publisher: BioMed Central (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

必須

頁

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87 87

都市

任意

ロンドン(London/[連合王国])

年月日

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2016年 6月 18日

URL

任意

DOI

任意

10.1186/s12933-016-0409-2 (→Scopusで検索)

PMID

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27317093 (→Scopusで検索)

CRID

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WOS

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000378875800001

Scopus

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2-s2.0-84975229374

評価値

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被引用数

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指導教員

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備考

任意

(英) Article.ELocationID: 10.1186/s12933-016-0409-2
(英) Article.DataBankList.DataBank.DataBankName: JPRN
(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: UMIN000012911
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) OtherID: PMC4912773
(英) KeywordList.Keyword: Carotid artery
(英) KeywordList.Keyword: Febuxostat
(英) KeywordList.Keyword: Hyperuricemia
(英) KeywordList.Keyword: Intima-media thickness (IMT)
(英) KeywordList.Keyword: Randomized controlled trial
(英) KeywordList.Keyword: Xanthine oxidase inhibitor

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