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著作: [楠瀬 賢也]/Cremer C. Paul/Tsutsui S. Rayji/Grimm A. Richard/Thomas D. James/Griffin P. Brian/Popović B. Zoran/Regurgitant volume informs rate of progressive cardiac dysfunction in asymptomatic patients with chronic aortic or mitral regurgitation./[JACC. Cardiovascular Imaging]

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EID
308477
EOID
825723
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0
LastModified
2016年7月27日(水) 11:53:52
Operator
三木 ちひろ
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TRUE
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Owner
楠瀬 賢也
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 楠瀬 賢也([徳島大学.病院.診療科.内科.循環器内科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Cremer C. Paul
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Tsutsui S. Rayji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Grimm A. Richard
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Thomas D. James
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Griffin P. Brian
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Popović B. Zoran
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Regurgitant volume informs rate of progressive cardiac dysfunction in asymptomatic patients with chronic aortic or mitral regurgitation.

副題 任意
要約 任意

(英) This study hypothesized that regurgitation severity, as determined by using the regurgitant volume index, would better delineate differential cardiac dysfunction in asymptomatic patients with moderate to severe aortic regurgitation (AR) and mitral regurgitation (MR). Frequent surveillance echocardiography is considered appropriate in asymptomatic patients with moderate to severe AR and MR. However, the evidence to support this practice and to define the appropriate frequency is limited. This was an observational cohort study of consecutive patients with moderate to severe asymptomatic AR or MR who underwent exercise echocardiography. Our cohort included 130 patients with moderate to severe asymptomatic MR and 130 patients with moderate to severe asymptomatic AR who were matched according to age and regurgitant volume index. All patients underwent yearly echocardiographic follow-up studies. Regurgitation severity was determined according to regurgitant volume index, with a level ≥30 ml/m(2) considered a marker of severe regurgitation. During follow-up, regardless of etiology, patients with severe regurgitation demonstrated increasing left ventricular volume indexes (4.2 ± 1.5 ml/m(2) per year; p = 0.01) and decreasing left ventricular ejection fractions (1.3 ± 0.4% per year; p = 0.002). In patients with moderate regurgitation, left ventricular volumes and ejection fractions did not significantly change. In addition, patients with severe regurgitation experienced a similar drop in contractility (end-systolic pressure/end-systolic volume ratio and single-beat pre-load recruitable stroke work) during follow-up independent of regurgitation etiology. Contractility parameters did not change in patients with moderate regurgitation. These asymptomatic patients with moderate AR or MR had stable cardiac function during 3 years of follow-up; thus, frequent echocardiography without a change in clinical status may not be necessary. In the setting of severe regurgitation, further cardiac deterioration occurred at a similar rate and manner irrespective of whether the dysfunction was related to AR or MR.

キーワード 推奨
  1. (英) Aortic Valve Insufficiency
  2. (英) Chronic Disease
  3. (英) Cohort Studies
  4. (英) Echocardiography
  5. (英) Female
  6. 心臓(heart)
  7. (英) Humans
  8. (英) Male
  9. (英) Middle Aged
  10. (英) Mitral Valve Insufficiency
  11. (英) Observer Variation
発行所 推奨
誌名 必須 JACC. Cardiovascular Imaging(American College of Cardiology)
(pISSN: 1936-878X, eISSN: 1876-7591)
ISSN 任意 1876-7591
ISSN: 1936-878X (pISSN: 1936-878X, eISSN: 1876-7591)
Title: JACC. Cardiovascular imaging
Title(ISO): JACC Cardiovasc Imaging
Publisher: American College of Cardiology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 8
必須 1
必須 14 23
都市 任意
年月日 必須 2015年 1月 初日
URL 任意
DOI 任意 10.1016/j.jcmg.2014.09.017    (→Scopusで検索)
PMID 任意 25499130    (→Scopusで検索)
NAID 任意
WOS 任意 000348181000003
Scopus 任意 2-s2.0-84922523599
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1016/j.jcmg.2014.09.017

  2. (英) Article.ELocationID: S1936-878X(14)00859-6

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Observational Study

  5. (英) KeywordList.Keyword: aortic regurgitation

  6. (英) KeywordList.Keyword: echocardiography

  7. (英) KeywordList.Keyword: mitral regurgitation

  8. (英) KeywordList.Keyword: natural history