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著作: [馬場 麻人]/Qin Chunlin/Brunn Jan C/Wygant James N/McIntyre Bradley W/Butler William T/Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development./[Matrix Biology]

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EID
308325
EOID
809413
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LastModified
2016年2月24日(水) 19:21:43
Operator
馬場 麻人
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馬場 麻人
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種別 必須
言語 必須 英語
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著者 必須
  1. 馬場 麻人([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔顎顔面形態学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Qin Chunlin
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Brunn Jan C
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Wygant James N
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) McIntyre Bradley W
    役割 任意
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    学籍番号 推奨
  6. (英) Butler William T
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題名 必須

(英) Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development.

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要約 任意

(英) Dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP) are acidic proteins found in the extracellular matrices of bones and teeth. Recent data from gene knockouts, along with those of gene mutations, indicate that these two phosphoproteins are critical for bone and tooth development and/or maintenance. However, the precise functions of the two proteins have not been elucidated. In order to gain insights into their functions in tooth formation, we performed systematic, comparative investigations on the immunolocalization of DMP1 and dentin sialoprotein (DSP, a cleaved fragment of DSPP), using the rat first molar at different developmental stages as a model. Immunohistochemistry (IHC) was performed with specific, monoclonal antibodies against the COOH-terminal fragments of DMP1 and against DSP. In 1-day- and 1-week-old rats, weak immunoreactions for DMP1 were observed in dentinal tubules while stronger reactions for DSP were seen in the tubules and predentin. In rats older than 2 weeks, immunoreactions for DMP1 were found in dentinal tubules, predentin and odontoblasts. In 5-week- and 8-week-old rats, strong immunoreactions for DMP1 were widely distributed in odontoblasts and predentin. The distribution pattern of DSP was strikingly similar to that of DMP1 after 2 weeks and the localization of each was distinctly different from that of bone sialoprotein (BSP). The unique colocalization of DMP1 and DSPP in tooth development suggests that the two proteins play complementary and/or synergistic roles in formation and maintenance of healthy teeth.

キーワード 推奨
  1. (英) Animals
  2. (英) Antibodies, Monoclonal
  3. (英) Bone and Bones
  4. (英) Extracellular Matrix Proteins
  5. (英) Gene Expression Regulation, Developmental
  6. 免疫組織化学(immunohistochemistry)
  7. (英) In Situ Hybridization
  8. (英) Integrin-Binding Sialoprotein
  9. (英) Molar
  10. (英) Odontoblasts
  11. (英) Phosphoproteins
  12. (英) Protein Precursors
  13. (英) Protein Structure, Tertiary
  14. (英) Rats
  15. (英) Rats, Sprague-Dawley
  16. (英) Sialoglycoproteins
  17. (英) Time Factors
発行所 推奨
誌名 必須 Matrix Biology(International Society for Matrix Biology)
(pISSN: 0945-053X, eISSN: 1569-1802)
ISSN 任意 0945-053X
ISSN: 0945-053X (pISSN: 0945-053X, eISSN: 1569-1802)
Title: Matrix biology : journal of the International Society for Matrix Biology
Title(ISO): Matrix Biol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 23
必須 6
必須 371 379
都市 任意
年月日 必須 2004年 10月 初日
URL 任意
DOI 任意 10.1016/j.matbio.2004.07.008    (→Scopusで検索)
PMID 任意 15533758    (→Scopusで検索)
NAID 任意
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  1. (英) PublicationType: Journal Article

  2. (英) PublicationType: Research Support, U.S. Gov't, P.H.S.