徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Miyata Atsushi/[馬場 麻人]/Oda Tsuyoshi/Ishikawa Isao/Takano Yoshiro/Diverse effects of c-src deficiency on molar tooth development and eruption in mice./[Archives of Histology and Cytology]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
308316
EOID
819163
Map
0
LastModified
2016年5月4日(水) 21:44:54
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
馬場 麻人
Read
継承
Write
継承
Delete
継承
種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Miyata Atsushi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 馬場 麻人([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔顎顔面形態学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Oda Tsuyoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Ishikawa Isao
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Takano Yoshiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Diverse effects of c-src deficiency on molar tooth development and eruption in mice.

副題 任意
要約 任意

(英) C-src deficiency is characterized by osteopetrosis due to impaired bone resorption by hypofunctional osteoclasts and the resultant failure of tooth eruption. In preliminary observations, we frequently encountered erupted molars in c-src deficient mice unlike in other osteopetrotic animals. Here we examine the effects of c-src deficiency on the development of molar teeth with an emphasis on the spatial relation of growing teeth with the surrounding bones. In c-src deficient mice, the magnitude of tooth impaction differed considerably among the types of molars; all maxillary 1st molars were totally impacted deep in the alveolar sockets, whereas most mandibular 1st molars fully erupted into oral cavity. Distribution of osteoclasts in the alveolar bone was identical among all types of molars, and electron microscopy revealed signs of bone resorbing activity in these osteoclasts despite the absence of a ruffled border. From early development, the alveolar space was much narrower in the upper molar tooth germs than in the lower ones in both wild type and homozygous animals, and particularly so in the upper 1st molars. Current observations thus indicate a significant contribution of "hypofunctional osteoclasts" in c-src deficient mice in molar tooth development except for the upper 1st molars, which appear to require highly functional osteoclasts to gain sufficient space for them to grow normally. Taken together, these findings on the seemingly tooth-type specific effects of c-src deficiency on the development and eruption of molar teeth in c-src deficient mice can be attributed to the given differential spatial relation of the respective tooth germs with the surrounding bones in the presence of hypofunctional osteoclasts.

キーワード 推奨
  1. (英) Acid Phosphatase
  2. (英) Animals
  3. (英) Cell Adhesion Molecules
  4. (英) Female
  5. (英) Fluorescent Antibody Technique, Indirect
  6. (英) Heterozygote
  7. (英) Histocytochemistry
  8. (英) Homozygote
  9. 免疫組織化学(immunohistochemistry)
  10. (英) Isoenzymes
  11. (英) Male
  12. (英) Mandible
  13. (英) Maxilla
  14. (英) Mice
  15. ノックアウトマウス(knockout mice)
  16. (英) Molar
  17. (英) Osteoblasts
  18. (英) Osteoclasts
  19. (英) Periodontal Ligament
  20. (英) Proto-Oncogene Proteins pp60(c-src)
  21. (英) Time Factors
  22. (英) Tooth Eruption
  23. (英) Tooth Germ
発行所 推奨
誌名 必須 Archives of Histology and Cytology(国際組織細胞学会)
(pISSN: 0914-9465, eISSN: 1349-1717)
ISSN 任意 0914-9465
ISSN: 0914-9465 (pISSN: 0914-9465, eISSN: 1349-1717)
Title: Archives of histology and cytology
Title(ISO): Arch Histol Cytol
Supplier: 国際組織細胞学会
Publisher: International Society of Histology and Cytology/Kokusai Soshiki Saibou Gakkai
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 70
必須 1
必須 63 78
都市 任意
年月日 必須 2007年 4月 初日
URL 任意
DOI 任意 10.1679/aohc.70.63    (→Scopusで検索)
PMID 任意 17558145    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Comparative Study

  2. (英) PublicationType: Journal Article

  3. (英) PublicationType: Research Support, Non-U.S. Gov't