徳島大学 教育・研究者情報データベース(EDB)

1. (英) Shibata S

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2. (英) Sakamoto Y

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3. 馬場 麻人([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔顎顔面形態学])

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4. (英) Qin C

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5. (英) Murakami G

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6. (英) Cho B H

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(英) An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses.

(英) Immunohistochemical localization of collagen types I, II, and X, aggrecan, versican, dentin matrix protein (DMP)-1, martix extracellular phosphoprotein (MEPE) were performed for Meckel's cartilage, cranial base cartilage, and mandibular condylar cartilage in human midterm fetuses; staining patterns within the condylar cartilage were compared to those within other cartilaginous structures. Mandibular condylar cartilage contained aggrecan; it also had more type I collagen and a thicker hypertrophic cell layer than the other two types of cartilage; these three characteristics are similar to those of the secondary cartilage of rodents. MEPE immunoreactivity was first evident in the cartilage matrix of all types of cartilage in the human fetuses and in Meckel's cartilage of mice and rats. MEPE immunoreactivity was enhanced in the deep layer of the hypertrophic cell layer and in the cartilaginous core of the bone trabeculae in the primary spongiosa. These results indicated that MEPE is a component of cartilage matrix and may be involved in cartilage mineralization. DMP-1 immunoreactivity first became evident in human bone lacunae walls and canaliculi; this pattern of expression was comparable to the pattern seen in rodents. In addition, chondroid bone was evident in the mandibular (glenoid) fossa of the temporal bone, and it had aggrecan, collagen types I and X, MEPE, and DMP-1 immunoreactivity; these findings indicated that chondroid bone in this region has phenotypic expression indicative of both hypertrophic chondrocytes and osteocytes.

1. (英) Aggrecans
2. (英) Animals
3. (英) Cartilage
4. コラーゲン(collagen)
5. (英) Collagen Type I
6. (英) Extracellular Matrix Proteins
7. (英) Female
8. (英) Fetus
9. (英) Gestational Age
10. (英) Glycoproteins
11. (英) Humans
12. (英) Mandibular Condyle
13. (英) Mice
14. (英) Phosphoproteins
15. (英) Pregnancy
16. (英) Pregnancy Trimester, Second
17. (英) Proliferating Cell Nuclear Antigen
18. (英) Rats

1. (英) PublicationType: Journal Article

2. (英) PublicationType: Research Support, Non-U.S. Gov't