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著作: [森垣 龍馬]/[後藤 惠]/Postsynaptic Density Protein 95 in the Striosome and Matrix Compartments of the Human Neostriatum./[Frontiers in Neuroanatomy]

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EID
307315
EOID
871638
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LastModified
2017年9月7日(木) 18:23:19
Operator
大家 隆弘
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森垣 龍馬
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
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  1. 森垣 龍馬([徳島大学.大学院医歯薬学研究部.医学域.共同研究講座.先端脳機能研究開発]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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  2. 後藤 惠([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.難治性神経疾患病態研究])
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(英) Postsynaptic Density Protein 95 in the Striosome and Matrix Compartments of the Human Neostriatum.

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(英) The human neostriatum consists of two functional subdivisions referred to as the striosome (patch) and matrix compartments. The striosome-matrix dopamine systems play a central role in cortico-thalamo-basal ganglia circuits, and their involvement is thought to underlie the genesis of multiple movement and behavioral disorders, and of drug addiction. Human neuropathology also has shown that striosomes and matrix have differential vulnerability patterns in several striatal neurodegenerative diseases. Postsynaptic density protein 95 (PSD-95), also known as disks large homolog 4, is a major scaffolding protein in the postsynaptic densities of dendritic spines. PSD-95 is now known to negatively regulate not only N-methyl-D-aspartate glutamate signaling, but also dopamine D1 signals at sites of postsynaptic transmission. Accordingly, a neuroprotective role for PSD-95 against dopamine D1 receptor (D1R)-mediated neurotoxicity in striatal neurodegeneration also has been suggested. Here, we used a highly sensitive immunohistochemistry technique to show that in the human neostriatum, PSD-95 is differentially concentrated in the striosome and matrix compartments, with a higher density of PSD-95 labeling in the matrix compartment than in the striosomes. This compartment-specific distribution of PSD-95 was strikingly complementary to that of D1R. In addition to the possible involvement of PSD-95-mediated synaptic function in compartment-specific dopamine signals, we suggest that the striosomes might be more susceptible to D1R-mediated neurotoxicity than the matrix compartment. This notion may provide new insight into the compartment-specific vulnerability of MSNs in striatal neurodegeneration.

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誌名 必須 Frontiers in Neuroanatomy(Frontiers Research Foundation)
(eISSN: 1662-5129)
ISSN 任意 1662-5129
ISSN: 1662-5129 (eISSN: 1662-5129)
Title: Frontiers in neuroanatomy
Title(ISO): Front Neuroanat
Publisher: Frontiers Media S.A.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 9
必須 ---
必須 154 154
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年月日 必須 2015年 11月 30日
URL 任意
DOI 任意 10.3389/fnana.2015.00154    (→Scopusで検索)
PMID 任意 26648848    (→Scopusで検索)
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  1. (英) PublicationType: Journal Article