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著作: Munkhzaya Munkhsaikhan/Matsuzaki Toshiya/[岩佐 武]/Tungalagsuvd Altankhuu/Kawami Takako/Kato Takeshi/Kuwahara Akira/Irahara Minoru/The suppressive effect of immune stress on LH secretion is absent in the early neonatal period in rats./[International Journal of Developmental Neuroscience]

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EID
307062
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1024239
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2021年11月25日(木) 11:25:57
Operator
三木 ちひろ
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岩佐 武
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
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著者 必須
  1. (英) Munkhzaya Munkhsaikhan
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Matsuzaki Toshiya
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 岩佐 武([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Tungalagsuvd Altankhuu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kawami Takako
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Kato Takeshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Kuwahara Akira
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    学籍番号 推奨
  8. (英) Irahara Minoru
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) The suppressive effect of immune stress on LH secretion is absent in the early neonatal period in rats.

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(英) Some physiological functions display weak responses to stress in the early neonatal period; i.e., they exhibit stress hyporesponse periods. In this study, we evaluated whether gonadotropin regulatory factors exhibit stress hyporesponsive periods in male and female rats. Rats were intraperitoneally injected with lipopolysaccharide (100g/kg) (LPS group) or saline (control group) on postnatal day (PND) 5, 10, 15, or 25. Then, their serum luteinizing hormone (LH) concentrations and hypothalamic mRNA levels of gonadotropin regulatory factors; i.e., kisspeptin (Kiss1), the kisspeptin receptor (Kiss1r), and gonadotropin-releasing hormone (GnRH), were measured at 2h after the injection. The hypothalamic mRNA levels of pro-inflammatory cytokines were also measured because they suppress gonadotropin secretion. The serum LH concentration of the LPS group was lower than that of the control group at PND25 in both sexes, but no such difference was seen at PND5, 10, or 15 in either sex. In both sexes, the hypothalamic tumor necrosis factor (TNF) and interleukin (IL)-6 mRNA expression levels of the LPS group were higher than those of the control group at PND25, but not at PND5 or 10. The hypothalamic IL-1 mRNA expression level of the LPS group was higher than that of the control group at all time points. The hypothalamic Kiss1, Kiss1r, and GnRH mRNA expression levels of the LPS and control groups did not differ at any time point in either sex. These findings suggest that gonadotropin regulatory factors exhibit stress hyporesponse periods. The hypothalamic-pituitary-gonadal axis (HPG) might become responsive to immune stress between PND15 and 25, which could be related to enhanced hypothalamic cytokine expression. The avoidance of infectious stress during the early neonatal period might be important for normal development of the HPG axis.

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誌名 必須 International Journal of Developmental Neuroscience(International Society for Developmental Neuroscience)
(pISSN: 0736-5748, eISSN: 1873-474X)
ISSN 任意 1873-474X
ISSN: 0736-5748 (pISSN: 0736-5748, eISSN: 1873-474X)
Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Title(ISO): Int J Dev Neurosci
Supplier: International Society for Development Neuroscience
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 46
必須 1
必須 38 43
都市 任意
年月日 必須 2015年 7月 15日
URL 任意
DOI 任意 10.1016/j.ijdevneu.2015.06.007    (→Scopusで検索)
PMID 任意 26188106    (→Scopusで検索)
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WOS 任意
Scopus 任意 2-s2.0-84938408588
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指導教員 推奨
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  1. (英) PublicationType: Journal Article