徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Tungalagsuvd Altankhuu/[松崎 利也]/[岩佐 武]/Munkhzaya Munkhsaikhan/Yiliyasi Mayila/Kawami Takako/[加藤 剛志]/[桑原 章]/[苛原 稔]/The expression of orexigenic and anorexigenic factors in middle-aged female rats that had been subjected to prenatal undernutrition./[International Journal of Developmental Neuroscience]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
307058
EOID
872973
Map
0
LastModified
2017年9月27日(水) 13:57:27
Operator
三好 小文
Avail
TRUE
Censor
0
Owner
岩佐 武
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tungalagsuvd Altankhuu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 松崎 利也
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 岩佐 武([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Munkhzaya Munkhsaikhan
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yiliyasi Mayila
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Kawami Takako
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 加藤 剛志([徳島大学.病院.中央診療施設等.地域産婦人科診療部])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 桑原 章
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 苛原 稔
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) The expression of orexigenic and anorexigenic factors in middle-aged female rats that had been subjected to prenatal undernutrition.

副題 任意
要約 任意

(英) Fetal growth retardation, which affects short- and long-term fetal brain development, is associated with metabolic, hematological, and thermal disturbances, which can increase the risk of metabolic syndrome later in life. Orexigenic and anorexigenic factors regulate food intake and energy expenditure. We studied how the expression of these factors was affected by food deprivation (FD) in middle-aged female rats that had been subjected to prenatal undernutrition. Eight pregnant rats were divided into two groups, the normal nutrition (NN) (n=4) group and the undernutrition (UN) (n=4) group, which received 50% (approximately 11g) of the daily food intake of the normal nutrition rats from day 13 of pregnancy to delivery. The pups from these dams were defined as the maternal NN (mNN) and maternal UN (mUN) groups, respectively. After weaning, all of the pups were housed and allowed ad libitum access to food and water. At the age of 6 months, both groups of pups were sub-divided into three groups. One group was allowed to consume normal amounts of food (Fed), and the other two groups were subjected to 24h or 48h FD (n=7-8 per group). The rats' serum leptin levels and hypothalamic mRNA expression levels of various orexigenic or anorexigenic factors were measured. In both the mNN and mUN rats, the serum leptin levels of the 24h and 48h FD groups tended to be lower than those of the Fed group, and the serum leptin levels of the 24h FD mUN rats and the Fed mUN rats differed significantly. The hypothalamic neuropeptide Y (NPY) mRNA expression levels of the 24h and 48h FD groups were significantly higher in the mUN rats than in the mNN rats. In addition, among the mUN rats the hypothalamic NPY mRNA expression levels of the 48h FD group were significantly higher than those of the Fed group. In both the mNN and mUN rats, prepro-orexin mRNA expression was lower in the 48h FD group than in the corresponding Fed group. Among the mUN rats, the 48h FD group exhibited significantly lower hypothalamic proopiomelanocortin (POMC) mRNA expression than the Fed group, and a similar tendency was seen among the mNN rats. Among the mNN rats, the 24h FD group displayed significantly higher hypothalamic leptin receptor (OBRb) mRNA levels than the Fed group. However, no such differences were seen among the mUN rats. As a result, the hypothalamic OBRb mRNA expression levels of the mUN rats in the 24h and 48h FD groups were lower than those of the corresponding mNN rat groups. These findings indicate that rats that are subjected to prenatal undernutrition exhibit upregulated expression of orexigenic factors and are more sensitive to FD in middle age, which might increase their risk of developing metabolic disorders in later life.

キーワード 推奨
発行所 推奨
誌名 必須 International Journal of Developmental Neuroscience(International Society for Developmental Neuroscience)
(pISSN: 0736-5748, eISSN: 1873-474X)
ISSN 任意 1873-474X
ISSN: 0736-5748 (pISSN: 0736-5748, eISSN: 1873-474X)
Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Title(ISO): Int J Dev Neurosci
Supplier: International Society for Development Neuroscience
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 49
必須
必須 1 5
都市 任意
年月日 必須 2016年 4月 初日
URL 任意
DOI 任意 10.1016/j.ijdevneu.2015.12.002    (→Scopusで検索)
PMID 任意 26702900    (→Scopusで検索)
CRID 任意
WOS 任意 000371941300001
Scopus 任意 2-s2.0-84958161611
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: JOURNAL ARTICLE