徳島大学 教育・研究者情報データベース(EDB)

1. (英) Omoto Katsuhiro

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2. (英) Iwasa Takuma

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3. (英) Afroz Shaista

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4. 宮城 麻友

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5. 大倉 一夫([徳島大学.病院.診療科.歯科.かみあわせ補綴科(第二補綴科)]/[徳島大学.歯学部.歯学科.機能維持系臨床歯学講座.顎機能咬合管理学])

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6. 松香 芳三([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.顎機能咬合再建学])

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(英) Preliminary study of neural excitation with positron emission tomography after tooth mechanical stimulation

(日) Dentists often cannot objectively find abnormalities in patients who complain of discomfort or abnormal sensation in their dental occlusion. We hypothesized that abnormal neural transmission from the tooth is related to this occlusal discomfort sensation. Chronic tooth contact habits may induce neural excitation from the tooth to the central nervous system, and may aggravate the sensation of discomfort in the central nervous system. However, the details of neural transmission from the tooth to the central nervous system are still unclear. In this study, we stimulated a rat premolar mechanically and observed activated bran sites using positron emission tomography (PET) and 18F-2-fluoro-2-deoxy-D-glucose (FDG). We anesthetized 5-7-week-old male rats using isoflurane inhalation anesthesia and stimulated the upper right premolar mechanically with an electric von Frey system (Model 1601C, IITC Instruments) by measuring mechanical pressure. Before the tooth mechanical stimulation, we injected FDG through the rat's caudal vein and then used a stimulation intensity of 100, 200 or 300 g. We recorded FDG accumulation with PET. The PET brain images were separated into four parts (right higher, left higher, right lower and left lower) for analysis and the peak value of striatal uptake (SUV) in each part was analyzed. The PET images showed that the accumulated FDG in the right lower part of the brain was higher with 300 g tooth stimulation than with 100 or 200 g. The data showed that the tooth stimulation site in the lower part of the brain was activated with tooth stimulation by comparing it with the other parts. We also measured SUV in the right and left sensory areas, motor area, hippocampus, trigeminal ganglia (TG) and spinal cord. The TG and sensory area showed more FDG accumulation compared with mouth opening.

1. (英) Tooth stimulation
2. (英) neural excitation
3. (英) positron emission tomography