徳島大学 教育・研究者情報データベース(EDB)

1. 沼田 周助([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])

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2. 木下 誠

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3. 田嶋 敦

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4. (英) Nishi Akira / (日) 西 晃 / (読) にし あきら

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5. 井本 逸勢

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6. 大森 哲郎

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(英) Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis.

(英) The results of meta-analyses conducted by previous association studies between total homocysteine and schizophrenia suggest that an elevated total homocysteine level is a risk factor for schizophrenia. However, observational studies have potential limitations, such as confounding and reverse causation. In the present study, we evaluated a causal relationship between plasma total homocysteine and schizophrenia by conducting a Mendelian randomization analysis. We used the MTHFR C677T polymorphism as an instrumental variable, which affects the plasma total homocysteine levels. To calculate the risk estimate for the association of this single nucleotide polymorphism (SNP) with schizophrenia, we conducted a meta-analysis of case-control studies that comprise a total of 11,042 patients with schizophrenia and 14,557 control subjects. We obtained an estimate for the association of this SNP with the plasma total homocysteine levels from a meta-analysis of genome-wide association studies comprising 44,147 individuals. By combining these two estimates, we demonstrated a significant effect of the plasma total homocysteine on schizophrenia risk, representing an OR of 2.15 (95 % CI = 1.39-3.32; p = 5.3 x 10(-4)) for schizophrenia per 1-SD increase in the natural log-transformed plasma total homocysteine levels. We provided evidence of a causal relationship between the plasma total homocysteine and schizophrenia, and this result will add insight into the pathology and treatment of schizophrenia.

1. (英) Case-Control Studies
2. (英) Genetic Predisposition to Disease
3. (英) Homocysteine
4. (英) Humans
5. (英) Mendelian Randomization Analysis
6. (英) Methylenetetrahydrofolate Reductase (NADPH2)
7. (英) Polymorphism, Single Nucleotide
8. (英) Risk Factors
9. 統合失調症(schizophrenia)

1. (英) Article.ELocationID: 10.1186/s12881-015-0197-7

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Meta-Analysis

4. (英) OtherID: PMC4557634