徳島大学 教育・研究者情報データベース(EDB)

1. 川人 伸次([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. (英) Katsutoshi Nakahata

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. (英) Toshiharu Azma

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. 黒田 泰弘

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. (英) David J Cook

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. (英) Hiroyuki Kinoshita

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Protective effects of anesthetics on vascular function related to K+ channels

(英) K(+) channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Especially, in vascular smooth muscle, the opening of adenosine triphosphate (ATP)-sensitive K(+) (KATP) channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. This activation also plays a role in tissues during pathophysiologic events such as ischemia, hypoxia, and vasodilatory shock. In this review, we will describe the physiological and pathophysiological roles of vascular smooth muscle KATP channels in relation to the effects of anesthetics. Although accumulated evidence suggests that many anesthetics modify the above function of K(+) channels as a metabolic sensor, further studies are certainly needed to resolve certain issues, especially in clinical settings of anesthesia use.

1. (英) anesthetics
2. (英) vascular function
3. (英) K+ channels

1. (英) Article.PublicationTypeList.PublicationType: Journal Article

2. (英) Article.PublicationTypeList.PublicationType: Review