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著作: Tsboi K./Sugimoto Y./Iwane A./[山本 圭]/Yamamoto S./Ichikawa A./Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice./[Endocrinology]

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EID
301588
EOID
1013355
Map
0
LastModified
2021年8月12日(木) 14:04:10
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
山本 圭
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨 国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tsboi K.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Sugimoto Y.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Iwane A.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 山本 圭([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.食料科学講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yamamoto S.
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Ichikawa A.
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice.

副題 任意
要約 任意

(英) PG production in uterine tissues is important for many physiological processes in late pregnancy, including parturition. We examined the expression of the PGH2 synthases, cyclooxygenase-1 (COX-1) and COX-2, in uterine tissues during late pregnancy, using PGF receptor-deficient (FP-/-) mice. Female FP-/- mice are unable to deliver normal fetuses at term, as they do not undergo luteolysis necessary for parturition. In wild-type mice, COX-1 messenger RNA (mRNA) was expressed in the endometrial epithelium, myometrium, and decidua throughout late pregnancy. The expression of COX-1 mRNA in the endometrial epithelium and myometrium decreased both in wild-type mice undergoing natural parturition and in FP-/- mice undergoing ovariectomy-induced parturition, but expression of COX-1 mRNA was enhanced in FP-/- mice at the expected term. In wild-type mice, COX-2 mRNA was not expressed in the myometrium before parturition, but was markedly induced during parturition. This induction of COX-2 was absent in FP-/- mice at the expected term, but was found during ovariectomy-induced parturition in these mice. Expression of COX-2 proteins was confirmed by immunohistochemical analysis. Thus, in uterine tissues, myometrial expression of COX-2 is closely associated with the occurrence of parturition, but uterine expression of COX-1 is induced much earlier and kept at a high level until parturition occurs. These results suggest that COX-1-derived PGs are responsible for the induction of luteolysis, and that COX-2-derived PGs play a role in the final pathway of parturition.

キーワード 推奨
  1. (英) Animals
  2. (英) Blotting, Northern
  3. (英) Corpus Luteum
  4. (英) Cyclooxygenase 1
  5. (英) Cyclooxygenase 2
  6. (英) Estradiol
  7. (英) Female
  8. (英) Immunohistochemistry
  9. (英) In Situ Hybridization
  10. (英) Isoenzymes
  11. (英) Labor, Obstetric
  12. (英) Membrane Proteins
  13. (英) Mice
  14. (英) Mice, Inbred C57BL
  15. (英) Mice, Knockout
  16. (英) Myometrium
  17. (英) Ovariectomy
  18. (英) Pregnancy
  19. (英) Pregnancy, Animal
  20. (英) Progesterone
  21. (英) Prostaglandin-Endoperoxide Synthases
  22. (英) Receptors, Prostaglandin
  23. (英) Uterus
発行所 推奨
誌名 必須 Endocrinology([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)
ISSN 任意 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 141
必須 1
必須 315 324
都市 任意
年月日 必須 2000年 1月 初日
URL 任意
DOI 任意 10.1210/endo.141.1.7236    (→Scopusで検索)
PMID 任意 10614653    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-0034463047
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't