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著作: Saito Kan/Fukumoto Emiko/Yamada Aya/Yuasa Kenji/Yoshizaki Keigo/[岩本 勉]/Saito Masahiro/Nakamura Takashi/Fukumoto Satoshi/Interaction between fibronectin and 1 integrin is essential for tooth development./[PLoS ONE]

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EID
300814
EOID
805469
Map
0
LastModified
2016年1月15日(金) 16:17:58
Operator
三木 ちひろ
Avail
TRUE
Censor
0
Owner
岩本 勉
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Saito Kan
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Fukumoto Emiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yamada Aya
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Yuasa Kenji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yoshizaki Keigo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 岩本 勉
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Saito Masahiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Nakamura Takashi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Fukumoto Satoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Interaction between fibronectin and 1 integrin is essential for tooth development.

副題 任意
要約 任意

(英) The dental epithelium and extracellular matrix interact to ensure that cell growth and differentiation lead to the formation of teeth of appropriate size and quality. To determine the role of fibronectin in differentiation of the dental epithelium and tooth formation, we analyzed its expression in developing incisors. Fibronectin mRNA was expressed during the presecretory stage in developing dental epithelium, decreased in the secretory and early maturation stages, and then reappeared during the late maturation stage. The binding of dental epithelial cells derived from postnatal day-1 molars to a fibronectin-coated dish was inhibited by the RGD but not RAD peptide, and by a β1 integrin-neutralizing antibody, suggesting that fibronectin-β1 integrin interactions contribute to dental epithelial-cell binding. Because fibronectin and β1 integrin are highly expressed in the dental mesenchyme, it is difficult to determine precisely how their interactions influence dental epithelial differentiation in vivo. Therefore, we analyzed β1 integrin conditional knockout mice (Intβ1lox-/lox-/K14-Cre) and found that they exhibited partial enamel hypoplasia, and delayed eruption of molars and differentiation of ameloblasts, but not of odontoblasts. Furthermore, a cyst-like structure was observed during late ameloblast maturation. Dental epithelial cells from knockout mice did not bind to fibronectin, and induction of ameloblastin expression in these cells by neurotrophic factor-4 was inhibited by treatment with RGD peptide or a fibronectin siRNA, suggesting that the epithelial interaction between fibronectin and β1 integrin is important for ameloblast differentiation and enamel formation.

キーワード 推奨
発行所 推奨
誌名 必須 PLoS ONE(Public Library of Science)
(eISSN: 1932-6203)
ISSN 任意 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 10
必須 4
必須 e0121667 e0121667
都市 任意
年月日 必須 2015年 4月 1日
URL 任意
DOI 任意 10.1371/journal.pone.0121667    (→Scopusで検索)
PMID 任意 25830530    (→Scopusで検索)
CRID 任意
WOS 任意 000352135600078
Scopus 任意 2-s2.0-84926611169
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1371/journal.pone.0121667

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) OtherID: PMC4382024