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著作: [岡村 永一]/Matsuzaki Hitomi/Campbell D. Andrew/Engel Douglas James/Fukamizu Akiyoshi/Tanimoto Keiji/All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice./[The FASEB journal]

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EID
300225
EOID
797987
Map
0
LastModified
2015年9月12日(土) 21:40:31
Operator
大家 隆弘
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TRUE
Censor
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Owner
岡村 永一
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 岡村 永一
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Matsuzaki Hitomi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Campbell D. Andrew
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Engel Douglas James
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Fukamizu Akiyoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Tanimoto Keiji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice.

副題 任意
要約 任意

(英) In primitive erythroid cells of human beta-globin locus transgenic mice (TgM), the locus control region (LCR)-proximal epsilon- and gamma-globin genes are transcribed, whereas the distal delta- and beta-globin genes are silent. It is generally accepted that the beta-globin gene is competitively suppressed by gamma-globin gene expression at this developmental stage. Previously, however, we observed that epsilon-globin gene expression was severely attenuated when its distance from the LCR was extended, implying that beta-globin gene might also be silenced because of its great distance from the LCR. Here, to clarify the beta-globin gene silencing mechanism, we established TgM lines carrying either gamma- or epsilon- plus gamma-globin promoter deletions, without significantly altering the distance between the beta-globin gene and the LCR. Precocious expression of delta- and beta-globin genes was observed in primitive erythroid cells of mutant, but not wild-type TgM, which was most evident when both the epsilon and gamma promoters were deleted. Thus, we clearly demonstrated that the repression of the delta- and beta-globin genes in primitive erythroid cells is dominated by competitive silencing by the epsilon- and gamma-globin gene promoters, and that epsilon- and the other beta-like globin genes might be activated by two distinct mechanisms by the LCR.

キーワード 推奨
  1. (英) Animals
  2. (英) Chromosomes, Artificial, Yeast
  3. (英) Erythroid Cells
  4. (英) Gene Expression Regulation
  5. (英) Humans
  6. (英) Locus Control Region
  7. (英) Mice
  8. (英) Mice, Transgenic
  9. (英) Saccharomyces cerevisiae
  10. (英) beta-Globins
発行所 推奨
誌名 必須 The FASEB journal([Federation of American Societies for Experimental Biology])
(pISSN: 0892-6638, eISSN: 1530-6860)
ISSN 任意 1530-6860
ISSN: 0892-6638 (pISSN: 0892-6638, eISSN: 1530-6860)
Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Title(ISO): FASEB J
Supplier: Federation of American Societies for Experimental Biology
Publisher: Federation of American Societies for Experimental Biology
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 23
必須 12
必須 4335 4343
都市 任意
年月日 必須 2009年 8月 18日
URL 任意
DOI 任意 10.1096/fj.09-137778    (→Scopusで検索)
PMID 任意 19690216    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1096/fj.09-137778

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  5. (英) OtherID: PMC2812047