298982: Sano Tomomi/Iwashita Misaki/Nagayasu Nagayasu/Yamashita Akiko/Shinjo Takanori/Hashikata Atsushi/Asano Tomoichiro/Kushiyama Akifumi/[石丸直澄]/[高浜洋介]/Nishimura Fusanori/Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling./[Obesity]

著作: Sano Tomomi/Iwashita Misaki/Nagayasu Nagayasu/Yamashita Akiko/Shinjo Takanori/Hashikata Atsushi/Asano Tomoichiro/Kushiyama Akifumi/[石丸直澄]/[高浜洋介]/Nishimura Fusanori/Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling./[Obesity]

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EID: 298982
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

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共著種別

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学究種別

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組織

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徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学(2015年4月1日〜)

著者

必須

(英) Sano Tomomi

役割任意

貢献度任意

学籍番号推奨
(英) Iwashita Misaki

役割任意

貢献度任意

学籍番号推奨
(英) Nagayasu Nagayasu

役割任意

貢献度任意

学籍番号推奨
(英) Yamashita Akiko

役割任意

貢献度任意

学籍番号推奨
(英) Shinjo Takanori

役割任意

貢献度任意

学籍番号推奨
(英) Hashikata Atsushi

役割任意

貢献度任意

学籍番号推奨
(英) Asano Tomoichiro

役割任意

貢献度任意

学籍番号推奨
(英) Kushiyama Akifumi

役割任意

貢献度任意

学籍番号推奨
石丸直澄([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])

役割任意

貢献度任意

学籍番号推奨
高浜洋介

役割任意

貢献度任意

学籍番号推奨
(英) Nishimura Fusanori

役割任意

貢献度任意

学籍番号推奨

題名

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(英) Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.

副題

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要約

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(英) Several chemokines play important roles in recruiting the monocyte/macrophage lineage into adipose tissues. We previously found CCL19 was highly expressed in adipocytes cocultured with macrophages stimulated by endotoxin. This study aimed to evaluate the role of CCL19-CCR7 axis on obesity and insulin resistance. Serum CCL19 concentration was examined in obese model mice challenged by endotoxin. CCL19 receptor-null, Ccr7(-/-), mice and wild-type mice fed a high-fat diet or normal diet were used to investigate the role of CCL19 signals on obesity-associated inflammation. CCL19 protein was elevated in the sera of obese model mice challenged by endotoxin. Ccr7(-/-) mice were protected from diet-induced obesity and insulin resistance. The adipose tissue and liver expression of inflammatory genes of Ccr7(-/-) mice was much lower than in diet-induced obese mice. Ccr7(-/-) mice were protected from fatty liver and dyslipidemia and exhibited increased thermogenesis on high-fat feeding. CCL19 attracts activated dendritic cells (DC). The expression of the DC markers, CD11b and 11c, was not observed in the adipose tissues of Ccr7(-/-) mice fed a high-fat diet, which might be closely associated with the protection of these mice from obesity. The CCL19-CCR7 pathway associates with the development of high-fat-induced obesity and insulin resistance.

キーワード

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発行所

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誌名

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Obesity(The Obesity Society)

(pISSN: 1930-7381, eISSN: 1930-739X)

ISSN	任意	1930-739X ISSN: 1930-7381 (pISSN: 1930-7381, eISSN: 1930-739X) Title: Obesity (Silver Spring, Md.) Title(ISO): Obesity (Silver Spring) Supplier: The Obesity Society Publisher: Wiley Publishing (NLM Catalog) (Wiley) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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1460 1471

都市

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年月日

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2015年 7月初日

URL

任意

DOI

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10.1002/oby.21127 (→Scopusで検索)

PMID

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26097021 (→Scopusで検索)

CRID

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WOS

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000356893400019

Scopus

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2-s2.0-84933178175

評価値

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被引用数

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指導教員

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備考

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(英) Article.ELocationID: 10.1002/oby.21127
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Sano Tomomi/Iwashita Misaki/Nagayasu Nagayasu/Yamashita Akiko/Shinjo Takanori/Hashikata Atsushi/Asano Tomoichiro/Kushiyama Akifumi/[石丸直澄]/[高浜洋介]/Nishimura Fusanori/Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling./[Obesity]

著作: Sano Tomomi/Iwashita Misaki/Nagayasu Nagayasu/Yamashita Akiko/Shinjo Takanori/Hashikata Atsushi/Asano Tomoichiro/Kushiyama Akifumi/[石丸 直澄]/[高浜 洋介]/Nishimura Fusanori/Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling./[Obesity]

著作: Sano Tomomi/Iwashita Misaki/Nagayasu Nagayasu/Yamashita Akiko/Shinjo Takanori/Hashikata Atsushi/Asano Tomoichiro/Kushiyama Akifumi/[石丸直澄]/[高浜洋介]/Nishimura Fusanori/Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling./[Obesity]