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著作: [廣島 佑香]/Hsu Kenneth/Tedla Nicodemus/Chung Yuen Ming/Chow Sharron/Herbert Cristan/Geczy Carolyn L/S100A8 induces IL-10 and protects against acute lung injury./[The Journal of Immunology]

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EID
298092
EOID
786524
Map
0
LastModified
2015年8月7日(金) 09:21:45
Operator
廣島 佑香
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廣島 佑香
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 廣島 佑香([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Hsu Kenneth
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    貢献度 任意
    学籍番号 推奨
  3. (英) Tedla Nicodemus
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    貢献度 任意
    学籍番号 推奨
  4. (英) Chung Yuen Ming
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    貢献度 任意
    学籍番号 推奨
  5. (英) Chow Sharron
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    貢献度 任意
    学籍番号 推奨
  6. (英) Herbert Cristan
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    貢献度 任意
    学籍番号 推奨
  7. (英) Geczy Carolyn L
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) S100A8 induces IL-10 and protects against acute lung injury.

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要約 任意

(英) S100A8 is considered proinflammatory by activating TLR4 and/or the receptor for advanced glycation end products. The aim was to investigate inflammatory effects of S100A8 in murine lung. S100A8 was administered to BALB/c mice by nasal inhalation and genes induced over a time-course assessed. LPS was introduced intranasally either alone or 2 h after pretreatment of mice with intranasal application of S100A8 or dexamethasone. A Cys(42)-Ala(42) mutant S100A8 mutant was used to assess whether S100A8's effects were via pathways that were dependent on reactive oxygen species. S100A8 induced IL-10 mRNA, and expression was apparent only in airway epithelial cells. Importantly, it suppressed acute lung injury provoked by LPS inhalation by suppressing mast-cell activation and induction of mediators orchestrating leukocyte recruitment, possibly by reducing NF-B activation via an IB/Akt pathway and by downmodulating pathways generating oxidative stress. The Cys(42)-Ala(42) S100A8 mutant did not induce IL-10 and was less immunosuppressive, indicating modulation by scavenging oxidants. S100A8 inhibition of LPS-mediated injury was as potent, and outcomes were remarkably similar to immunosuppression by dexamethasone. We challenge the notion that S100A8 is an agonist for TLR4 or the receptor for advanced glycation end products. S100A8 induced IL-10 in vivo and initiates a feedback loop that attenuates acute lung injury.

キーワード 推奨
  1. (英) Acute Lung Injury
  2. (英) Anti-Inflammatory Agents
発行所 推奨
誌名 必須 The Journal of Immunology([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
ISSN 任意 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 192
必須 6
必須 2800 2811
都市 任意
年月日 必須 2014年 2月 14日
URL 任意
DOI 任意 10.4049/jimmunol.1302556    (→Scopusで検索)
PMID 任意 24532576    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
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指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article

  2. (英) PublicationType: Research Support, Non-U.S. Gov't