徳島大学 教育・研究者情報データベース(EDB)

1. 山本 伸昭([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学])

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2. 寺澤 由佳

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3. 里見 淳一郎

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4. (英) Waka Sakai / (日) 酒井 和香 / (読) さかい わか

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5. 原田 雅史([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])

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6. 和泉 唯信([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])

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7. 永廣 信治

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8. 梶 龍兒([徳島大学.研究支援・産官学連携センター])

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(英) Predictors of neurologic deterioration in patients with small-vessel occlusion and infarcts in the territory of perforating arteries

(英) It is difficult to predict neurologic deterioration in patients with small-vessel occlusion (SVO), that is, small infarcts in the territory of cerebral perforating arteries. We reviewed 110 patients with SVO who were admitted to our hospital. We divided them into groups with (n = 32, group 1) and without deterioration (n = 78, group 2) and evaluated their medical records, risk factors, magnetic resonance imaging findings, grade of periventricular hyperintensity (PVH), maximum diameter of the infarct area, and the number of slices showing infarcts on diffusion-weighted images (DWI). Our study population consisted of 110 patients (71 males and 39 females; mean age 69.2 years): 32 (29%) did and 78 (71%) did not suffer deterioration. By univariate analysis, the age, current smoking, history of stroke, maximum diameter of the infarcted area, number of DWI slices with infarcts, frequency of PVH, and PVH grade based on Fazekas classification differed significantly between the 2 groups. By multivariate analysis, conventional risk factors other than PVH and history of stroke were not associated with neurologic deterioration (PVH grade ≥ 2 versus PVH grade ≤ 1, odds ratio 6.72, P = .006; with stroke versus without stroke, odds ratio .21, P = .049). We also found that higher the PVH grade, the worse the National Institutes of Health Stroke Scale score at the time of discharge. PVH and without history of stroke are independently associated with neurologic deterioration in patients with SVO.

1. (英) Aged
2. (英) Aged, 80 and over
3. (英) Brain Infarction
4. (英) Cerebral Arteries
5. (英) Cerebral Ventricles
6. (英) Diffusion Magnetic Resonance Imaging
7. (英) Female
8. (英) Humans
9. (英) Intracranial Thrombosis
10. 磁気共鳴映像法(magnetic resonance imaging)
11. (英) Male
12. (英) Middle Aged
13. (英) Odds Ratio
14. (英) Predictive Value of Tests
15. (英) Risk Factors
16. 喫煙(smoking)
17. (英) PVH grade
18. (英) neurologic deterioration
19. (英) predictors
20. (英) small vessel occlusion

1. (英) Article.ELocationID: 10.1016/j.jstrokecerebrovasdis.2014.04.011

2. (英) Article.ELocationID: S1052-3057(14)00197-9

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) KeywordList.Keyword: PVH grade

5. (英) KeywordList.Keyword: neurologic deterioration

6. (英) KeywordList.Keyword: predictors

7. (英) KeywordList.Keyword: small-vessel occlusion