徳島大学 教育・研究者情報データベース(EDB)

1. 埴淵 昌毅([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域呼吸器・血液・代謝内科学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. (英) Kim SJ

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. (英) Fidler IJ

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. 西岡 安彦([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives

(英) Brain metastases occur in 20-40% of patients with advanced malignancies and lung cancer is one of the most common causes of brain metastases. The occurrence of brain metastases is associated with poor prognosis and high morbidity in patients with advanced lung cancer, even after intensive multimodal therapy. Progress in treating brain metastases has been hampered by a lack of model systems, a lack of human tissue samples, and the exclusion of brain metastatic patients from many clinical trials. While the biology of brain metastasis is still poorly understood, it is encouraging to see more efforts are beginning to be directed toward the study of brain metastasis. During the multi-step process of metastasis, functional significance of gene expressions, changes in brain vasculature, abnormal secretion of soluble factors and activation of autocrine/paracrine signaling are considered to contribute to the brain metastasis development. A better understanding of the mechanism of this disease will help us to identify the appropriate therapeutic strategies, which leads to circumvent brain metastases. Recent findings on the biology of lung cancer brain metastases and translational leads identified by molecular studies are discussed in this review.

1. (英) Article.PublicationTypeList.PublicationType: Journal Article