297100: Omoto Katsuhiro/Maruhama K/Terayama R/Yamamoto Yumiko/Matsushita Osam/Sugimoto Tomosada/Oguma Keiji/[松香芳三]/Cross-excitation in peripheral sensory ganglia is associated with pain transmission/[Toxins]

著作: Omoto Katsuhiro/Maruhama K/Terayama R/Yamamoto Yumiko/Matsushita Osam/Sugimoto Tomosada/Oguma Keiji/[松香芳三]/Cross-excitation in peripheral sensory ganglia is associated with pain transmission/[Toxins]

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EID: 297100
EOID: 923785
Map: 0
LastModified: 2018年8月29日(水) 15:38:30
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Owner: 松香芳三
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種別

必須

学術論文(審査論文)

言語

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英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

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(英) Omoto Katsuhiro

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学籍番号推奨
(英) Maruhama K

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貢献度任意

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(英) Terayama R

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貢献度任意

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(英) Yamamoto Yumiko

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貢献度任意

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(英) Matsushita Osam

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貢献度任意

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(英) Sugimoto Tomosada

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貢献度任意

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(英) Oguma Keiji

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貢献度任意

学籍番号推奨
松香芳三([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.顎機能咬合再建学])

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題名

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(英) Cross-excitation in peripheral sensory ganglia is associated with pain transmission

副題

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要約

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(英) Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.

キーワード

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発行所

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誌名

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Toxins(Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)

(eISSN: 2072-6651)

ISSN	任意	2072-6651 ISSN: 2072-6651 (eISSN: 2072-6651) Title: Toxins Title(ISO): Toxins (Basel) Publisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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2906 2917

都市

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年月日

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2015年 8月 4日

URL

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DOI

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10.3390/toxins7082906 (→Scopusで検索)

PMID

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26248078 (→Scopusで検索)

CRID

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WOS

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000360202700014

Scopus

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2-s2.0-84940830023

機関リポジトリ

111969

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被引用数

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指導教員

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備考

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(英) Article.ELocationID: 10.3390/toxins7082906
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) OtherID: PMC4549732
(英) KeywordList.Keyword: botulinum toxin
(英) KeywordList.Keyword: dorsal root ganglion
(英) KeywordList.Keyword: mechanical allodynia
(英) KeywordList.Keyword: transmitter release

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Omoto Katsuhiro/Maruhama K/Terayama R/Yamamoto Yumiko/Matsushita Osam/Sugimoto Tomosada/Oguma Keiji/[松香芳三]/Cross-excitation in peripheral sensory ganglia is associated with pain transmission/[Toxins]

著作: Omoto Katsuhiro/Maruhama K/Terayama R/Yamamoto Yumiko/Matsushita Osam/Sugimoto Tomosada/Oguma Keiji/[松香 芳三]/Cross-excitation in peripheral sensory ganglia is associated with pain transmission/[Toxins]

著作: Omoto Katsuhiro/Maruhama K/Terayama R/Yamamoto Yumiko/Matsushita Osam/Sugimoto Tomosada/Oguma Keiji/[松香芳三]/Cross-excitation in peripheral sensory ganglia is associated with pain transmission/[Toxins]