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著作: Tara Shuhei/[黒部 裕嗣]/Rocco A. Kevin/Maxfield W. Mark/Best A. Cameron/Yi Tai/Naito Yuji/Breuer K. Christopher/Shinoka Toshiharu/Well-organized neointima of large-pore poly(l-lactic acid) vascular graft coated with poly(l-lactic-co--caprolactone) prevents calcific deposition compared to small-pore electrospun poly(l-lactic acid) graft in a mouse aortic implantation model./[Atherosclerosis]

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EID
296589
EOID
1060090
Map
0
LastModified
2022年10月5日(水) 11:10:00
Operator
三木 ちひろ
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TRUE
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0
Owner
[科長]/[徳島大学.病院.診療科.外科]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tara Shuhei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 黒部 裕嗣
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Rocco A. Kevin
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Maxfield W. Mark
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Best A. Cameron
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Yi Tai
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Naito Yuji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Breuer K. Christopher
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Shinoka Toshiharu
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Well-organized neointima of large-pore poly(l-lactic acid) vascular graft coated with poly(l-lactic-co--caprolactone) prevents calcific deposition compared to small-pore electrospun poly(l-lactic acid) graft in a mouse aortic implantation model.

副題 任意
要約 任意

(英) Tissue engineering techniques have emerged that allow bioresorbable grafts to be implanted that restore function and transform into biologically active arteries. However, these implants are susceptible to calcification during the remodeling process. The objective of this study was to evaluate the role of pore size of bioabsorbable grafts in the development of calcification. Two types of grafts were prepared: a large-pore graft constructed of poly(L-lactic acid) (PLA) fibers coated with poly(L-lactide-co-ϵ-caprolactone) (PLCL) (PLA-PLCL), and a small-pore graft made of electrospun PLA nanofibers (PLA-nano). Twenty-eight PLA-PLCL grafts and twenty-five PLA-nano grafts were implanted as infra-renal aortic interposition conduits in 8-week-old female SCID/Bg mice, and followed for 12 months after implantation. Large-pore PLA-PLCL grafts induced a well-organized neointima after 12 months, and Alizarin Red S staining showed neointimal calcification only in the thin neointima of small-pore PLA-nano grafts. At 12 months, macrophage infiltration, evaluated by F4/80 staining, was observed in the thin neointima of the PLA-nano graft, and there were few vascular smooth muscle cells (VSMCs) in this layer. On the other hand, the neointima of the PLA-PLCL graft was composed of abundant VSMCs, and a lower density of macrophages (F4/80 positive cells, PLA-PLCL; 68.1 ± 41.4/mm(2) vs PLA-nano; 188.3 ± 41.9/mm(2), p = 0.007). The VSMCs of PLA-PLCL graft expressed transcription factors of both osteoblasts and osteoclasts. These findings demonstrate that in mouse arterial circulation, large-pore PLA-PLCL grafts created a well-organized neointima and prevented calcific deposition compared to small-pore, electrospun PLA-nano grafts.

キーワード 推奨
  1. (英) Animals
  2. (英) Arteries
  3. (英) Calcinosis
  4. コラーゲン(collagen)
  5. (英) Elastin
  6. 女性(female)
  7. 炎症(inflammation)
  8. (英) Lactic Acid
  9. (英) Macrophages
  10. (英) Mice
  11. (英) Mice, SCID
  12. (英) Microscopy, Electron, Scanning
  13. (英) Models, Animal
  14. (英) Neointima
  15. (英) Osteoblasts
  16. (英) Osteoclasts
  17. (英) Osteogenesis
  18. (英) Polyesters
  19. (英) Polymers
  20. (英) Porosity
  21. 再生医学(tissue engineering)
  22. (英) Transcription Factors
  23. (英) Vascular Grafting
発行所 推奨
誌名 必須 Atherosclerosis(European Atherosclerosis Society)
(pISSN: 0021-9150, eISSN: 1879-1484)
ISSN 任意 1879-1484
ISSN: 0021-9150 (pISSN: 0021-9150, eISSN: 1879-1484)
Title: Atherosclerosis
Title(ISO): Atherosclerosis
Publisher: Elsevier Ireland Ltd
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 237
必須 2
必須 684 691
都市 任意
年月日 必須 2014年 10月 17日
URL 任意
DOI 任意 10.1016/j.atherosclerosis.2014.09.030    (→Scopusで検索)
PMID 任意 25463106    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1016/j.atherosclerosis.2014.09.030

  2. (英) Article.ELocationID: S0021-9150(14)01439-7

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  5. (英) OtherID: NIHMS640781 [Available on 12/01/15]

  6. (英) OtherID: PMC4262639 [Available on 12/01/15]

  7. (英) KeywordList.Keyword: Atherosclerotic cardiovascular diseases

  8. (英) KeywordList.Keyword: Bioabsorbable grafts

  9. (英) KeywordList.Keyword: Calcification

  10. (英) KeywordList.Keyword: Electrospinning technique

  11. (英) KeywordList.Keyword: Pore size

  12. (英) KeywordList.Keyword: Tissue engineering