著作: 岡 真紀子/[丹羽 保晴]/[馬渡 一諭]/Hiasa Yoshikazu/[中屋 豊]/A novel peptide of endothelin family, 31 amino-acid length endothelin in patients with acute myocardial infarction./[The Journal of Medical Investigation : JMI]
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削除する| 種別 | 必須 | ||||
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| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | ||||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) A novel peptide of endothelin family, 31 amino-acid length endothelin in patients with acute myocardial infarction. |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Human chymase converts big endothelin (ET)-1 to 31-amino acid length ET-1 {ET-1(1-31)} that also possesses a potent vasoconstrictive action. In addition, ET-1(1-31) is an intermediate peptide, which is then readily transformed to mature ET-1 by the neutral endopeptidase 24-11. To investigate the relevance of pathophysiology of ET-1(1-31) in vivo, we have developed specific sandwich-type, enzyme-linked immunosorbent assay to measure the plasma concentration of ET-1(1-31) in healthy volunteers and patients with myocardial infarction. The plasma concentrations of ET-1(1-31) in healthy volunteers were 24.8 ± 5.2 pg/ml (n=11). ET-1(1-31) concentration in plasma was elevated in patients with acute myocardial infarction, and its elevation was several times higher and lasted longer than that of ET-1. In addition, tissue concentration of ET-1(1-31) in the myocardium from a patient with acute myocardial infarction was extremely high (12729.8 ± 2617.7 pg/mg protein). These results suggest that ET-1(1-31) may play some pathological roles in the remodeling, especially in sites where inflammatory cells produced a large amount of proteases, such as myocardial infarction. |
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| キーワード | 推奨 | ||||
| 発行所 | 推奨 | ||||
| 誌名 | 必須 |
The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
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| 巻 | 必須 | 61 | |||
| 号 | 必須 | 3-4 | |||
| 頁 | 必須 | 298 305 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2014年 0月 初日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.2152/jmi.61.298 (→Scopusで検索) | |||
| PMID | 任意 | 25264048 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | 2-s2.0-84907504152 | |||
| 機関リポジトリ | 109577 | ||||
| 評価値 | 任意 | ||||
| 被引用数 | 任意 | ||||
| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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