徳島大学 教育・研究者情報データベース(EDB)

1. 三好 人正

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. 宮本 弘志([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. 郷司 敬洋

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. 谷口 達哉

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. 友成 哲([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.消化器内科])

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. 曽我部 正弘([徳島大学.キャンパスライフ健康支援センター])

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. 木村 哲夫

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 北村 晋志

   役割	任意
   貢献度	任意
   学籍番号	推奨

9. 岡本 耕一([徳島大学.病院.診療科.内科.消化器内科])

   役割	任意
   貢献度	任意
   学籍番号	推奨

10. 藤野 泰輝

    役割	任意
    貢献度	任意
    学籍番号	推奨

11. 六車 直樹

    役割	任意
    貢献度	任意
    学籍番号	推奨

12. 岡久 稔也([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域総合医療学]/[徳島大学.病院.診療科.内科.消化器内科])

    役割	任意
    貢献度	任意
    学籍番号	推奨

13. 高山 哲治([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])

    役割	任意
    貢献度	任意
    学籍番号	推奨

(英) Serum diamine oxidase activity as a predictor of gastrointestinal toxicity and malnutrition due to anticancer drugs.

(英) Objective evaluation of intestinal mucosal damage due to anticancer drugs is generally difficult. Serum diamine oxidase (DAO) activity is reported to reflect the integrity and maturity of the small intestinal mucosa. Therefore, we investigated whether serum DAO activity is an indicator of gastrointestinal toxicity or nutritional status in patients receiving chemotherapy. We prospectively enrolled 20 patients with unresectable metastatic gastric cancer who received oral S-1 (80 mg/m(2) ) on days 1-14, and intravenous cisplatin (60 mg/m(2) ) and docetaxel (50 mg/m(2) ) on day 8 every 3 weeks. Serum DAO activity was measured by colorimetry. Gastrointestinal toxicity was evaluated by CTCAE v4.0. Endoscopic examination and biopsy of duodenal mucosa assessed mucosal damage. Malnutrition was evaluated by measuring serum total protein and albumin levels. Serum DAO activity decreased step-by-step significantly during anticancer drug treatment and recovered after drug holidays. In all 14 patients who experienced diarrhea, serum DAO activity significantly decreased prior to diarrhea onset. Percent decrease in DAO activity was significantly correlated with severity of diarrhea. Significant correlation was observed between percent decrease in DAO activity and percent decrease in duodenal villus height or surface area from baseline. There were also significant correlations between percent decrease in serum DAO activity at day 14 and percent decrease in serum total protein or albumin levels at day 21 from baseline. Serum DAO activity sensitively indicates gastrointestinal damage prior to symptom onset and can be a useful predictor of intestinal mucosal damage and nutritional status in patients receiving chemotherapy.

1. (英) Article.ELocationID: 10.1111/jgh.13004

2. (英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE

3. (英) KeywordList.Keyword: anticancer drugs

4. (英) KeywordList.Keyword: diamine oxidase

5. (英) KeywordList.Keyword: diarrhea

6. (英) KeywordList.Keyword: gastrointestinal toxicity

7. (英) KeywordList.Keyword: malnutrition