徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.医用画像機器工学(2015年4月1日〜)

1. 田中 義浩

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2. 藤本 憲市

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3. 吉永 哲哉([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.医用画像機器工学])

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(英) Dose-volume constrained optimization in intensity-modulated radiation therapy treatment planning

(英) We present a novel optimization method to handle dose-volume constraints (DVCs) directly in intensity-modulated radiation therapy (IMRT) treatment planning based on the idea of continuous dynamical methods. Most of the conventional methods are constructed for solving inconsistent inverse problems with, e.g., dose-volume based objective functions, and one expects to obtain a feasible solution that minimally violates the DVCs. We introduce the concept of `acceptable' meaning that there exists a nonempty set of radiation beam weights satisfying the given DVCs and resolve the issue that the objective and evaluation are different in the conventional planning approach. We apply the initial-value problem of the proposed dynamical system to an acceptable and inconsistent inverse problem and prove that the convergence to an equilibrium in the acceptable set of solutions is theoretically guaranteed by using the Lyapunov theorem. Indeed, we confirmed that we can obtain acceptable beam weights through numerical experiments using phantom data simulating a clinical setup for an acceptable and inconsistent IMRT planning system.

1. (英) Intensity-modulated radiation therapy treatment planning
2. (英) Dose-volume constraints
3. (英) Dose-volume constrained optimization
4. 逆問題(inverse problem)
5. (英) Stability of solution