著作: [殿谷 一朗]/[高橋 光彦]/[油形 公則]/[佐藤 亮祐]/[二川 健]/[安井 夏生]/[西良 浩一]/Osteoactivin attenuates skeletal muscle fibrosis after distraction osteogenesis by promoting extracellular matrix degradation/remodeling./[Journal of Pediatric Orthopaedics. Part B]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Osteoactivin attenuates skeletal muscle fibrosis after distraction osteogenesis by promoting extracellular matrix degradation/remodeling. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) The aim of this study was to determine whether osteoactivin attenuated skeletal muscle fibrosis caused by distraction osteogenesis. Tibial osteotomies were performed on wild-type and osteoactivin-transgenic (OA-Tg) mice, and tibiae were distracted for 2 weeks. Ankle plantar flexion torque and the gastrocnemius muscles were analyzed. The amount and area of collagenous tissue and the passive torque were reduced in the OA-Tg group at 8 weeks after osteotomy. Transcript levels of matrix metalloprotease (mmp)-3 and MMP-9 were upregulated, and MMP-3 and MMP-9 proteins were increased in the OA-Tg group. Osteoactivin-mediated increase in MMPs may attenuate skeletal muscle fibrosis. |
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キーワード | 推奨 | ||||
発行所 | 推奨 | ||||
誌名 | 必須 |
Journal of Pediatric Orthopaedics. Part B(European Paediatric Orthopaedic Society/Pediatric Orthopaedic Society of North America)
(pISSN: 1060-152X, eISSN: 1473-5865)
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巻 | 必須 | 24 | |||
号 | 必須 | 2 | |||
頁 | 必須 | 162 169 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2015年 3月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1097/BPB.0000000000000117 (→Scopusで検索) | |||
PMID | 任意 | 25405936 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | 000349000900016 | |||
Scopus | 任意 | 2-s2.0-84922398143 | |||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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