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著作: Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study Group./Design and baseline characteristics of a study of primary prevention of coronary events with pravastatin among Japanese with mildly elevated cholesterol levels./[Circulation Journal]

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2018年6月7日(木) 14:49:18
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三木 ちひろ
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[副研究部長]/[徳島大学.大学院医歯薬学研究部]
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
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  1. (英) Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study Group.
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    学籍番号 推奨
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(英) Design and baseline characteristics of a study of primary prevention of coronary events with pravastatin among Japanese with mildly elevated cholesterol levels.

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(英) BACKGROUND: Although cholesterol management reportedly reduces fatal and non-fatal coronary heart disease (CHD) events in subjects with or without evident atherosclerotic disease, it is still uncertain whether these benefits extend to Japanese.METHODS AND RESULTS: The study group comprised 8,009 subjects with mildly elevated total cholesterol who were randomized to treatment with 10-20 mg pravastatin plus diet (2,691 women, 1,267 men) or diet alone (2,758 women, 1,293 men). The groups were extremely well balanced with respect to baseline demographics and risk factors such as blood pressure and plasma lipids. Over a 5-year period of follow-up, the primary end-points will be a composite of fatal and non-fatal coronary events. Secondary end-points will include stroke and transient ischemic attack, all cardiovascular events and total mortality.CONCLUSIONS: The 2 groups will be followed up until the end of March 2004 and end-points will be analyzed by full analysis set.

キーワード 推奨
  1. (英) Adult
  2. (英) Aged
  3. (英) Anticholesteremic Agents
  4. (英) Blood Glucose
  5. (英) Blood Pressure
  6. (英) Body Mass Index
  7. (英) Coronary Disease
  8. (英) Diet
  9. (英) Female
  10. (英) Follow-Up Studies
  11. (英) Humans
  12. (英) Lipids
  13. (英) Male
  14. (英) Middle Aged
  15. (英) Patient Selection
  16. (英) Pravastatin
  17. (英) Primary Prevention
  18. (英) Randomized Controlled Trials as Topic
  19. (英) Retrospective Studies
  20. (英) Time Factors
発行所 推奨 社団法人 日本循環器学会
誌名 必須 Circulation Journal([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)
ISSN 任意 1346-9843
ISSN: 1346-9843 (pISSN: 1346-9843, eISSN: 1347-4820)
Title: Circulation journal : official journal of the Japanese Circulation Society
Title(ISO): Circ J
Supplier: 社団法人日本循環器学会
Publisher: Japanese Circulation Society
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 68
必須 9
必須 860 867
都市 任意
年月日 必須 2004年 8月 25日
URL 任意
DOI 任意 10.1253/circj.68.860    (→Scopusで検索)
PMID 任意 15329509    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Clinical Trial

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Multicenter Study

  4. (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial

  5. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't