288024: Ogawa Satoshi/Yamashita Takeshi/Aizawa Yoshifusa/Atarashi Hirotsugu/Inoue Hiroshi/Ohe Tohru/Ohtsu Hiroshi/Okumura Ken/Katoh Takao/Kamakura Shiro/Kumagai Koichiro/Kurachi Yoshihisa/Kodama Itsuo/Koretsune Yukihiro/Saikawa Tetsunori/Sakurai Masayuki/Sugi Kaoru/Tabuchi Toshifumi/Nakaya Haruaki/Nakayama Toshio/Hirai Makoto/Fukatani Masahiko/Mitamura Hideo/J-RHYTHM Investigators/Optimal treatment strategy for patients with paroxysmal atrial fibrillation: J-RHYTHM Study./[Circulation Journal]

著作: Ogawa Satoshi/Yamashita Takeshi/Aizawa Yoshifusa/Atarashi Hirotsugu/Inoue Hiroshi/Ohe Tohru/Ohtsu Hiroshi/Okumura Ken/Katoh Takao/Kamakura Shiro/Kumagai Koichiro/Kurachi Yoshihisa/Kodama Itsuo/Koretsune Yukihiro/Saikawa Tetsunori/Sakurai Masayuki/Sugi Kaoru/Tabuchi Toshifumi/Nakaya Haruaki/Nakayama Toshio/Hirai Makoto/Fukatani Masahiko/Mitamura Hideo/J-RHYTHM Investigators/Optimal treatment strategy for patients with paroxysmal atrial fibrillation: J-RHYTHM Study./[Circulation Journal]

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EID: 288024
EOID: 908153
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LastModified: 2018年6月8日(金) 17:17:17
Operator: 三木ちひろ
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Owner: [副研究部長]/[徳島大学.大学院医歯薬学研究部]
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

著者

必須

(英) Ogawa Satoshi

役割任意

貢献度任意

学籍番号推奨
(英) Yamashita Takeshi

役割任意

貢献度任意

学籍番号推奨
(英) Aizawa Yoshifusa

役割任意

貢献度任意

学籍番号推奨
(英) Atarashi Hirotsugu

役割任意

貢献度任意

学籍番号推奨
(英) Inoue Hiroshi

役割任意

貢献度任意

学籍番号推奨
(英) Ohe Tohru

役割任意

貢献度任意

学籍番号推奨
(英) Ohtsu Hiroshi

役割任意

貢献度任意

学籍番号推奨
(英) Okumura Ken

役割任意

貢献度任意

学籍番号推奨
(英) Katoh Takao

役割任意

貢献度任意

学籍番号推奨
(英) Kamakura Shiro

役割任意

貢献度任意

学籍番号推奨
(英) Kumagai Koichiro

役割任意

貢献度任意

学籍番号推奨
(英) Kurachi Yoshihisa

役割任意

貢献度任意

学籍番号推奨
(英) Kodama Itsuo

役割任意

貢献度任意

学籍番号推奨
(英) Koretsune Yukihiro

役割任意

貢献度任意

学籍番号推奨
(英) Saikawa Tetsunori

役割任意

貢献度任意

学籍番号推奨
(英) Sakurai Masayuki

役割任意

貢献度任意

学籍番号推奨
(英) Sugi Kaoru

役割任意

貢献度任意

学籍番号推奨
(英) Tabuchi Toshifumi

役割任意

貢献度任意

学籍番号推奨
(英) Nakaya Haruaki

役割任意

貢献度任意

学籍番号推奨
(英) Nakayama Toshio

役割任意

貢献度任意

学籍番号推奨
(英) Hirai Makoto

役割任意

貢献度任意

学籍番号推奨
(英) Fukatani Masahiko

役割任意

貢献度任意

学籍番号推奨
(英) Mitamura Hideo

役割任意

貢献度任意

学籍番号推奨
(英) J-RHYTHM Investigators

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Optimal treatment strategy for patients with paroxysmal atrial fibrillation: J-RHYTHM Study.

副題

任意

要約

任意

(英) Background Although previous clinical trials demonstrated the non-inferiority of a rate control to rhythm control strategy for management of atrial fibrillation (AF), the optimal treatment strategy for paroxysmal AF (PAF) remains unclear. Methods and Results A randomized, multicenter comparison of rate control vs rhythm control in Japanese patients with PAF (the Japanese Rhythm Management Trial for Atrial Fibrillation (J-RHYTHM) study) was conducted. The primary endpoint was a composite of total mortality, symptomatic cerebral infarction, systemic embolism, major bleeding, hospitalization for heart failure, or physical/psychological disability requiring alteration of treatment strategy. In the study, 823 patients with PAF were followed for a mean period of 578 days. The primary endpoint occurred in 64 patients (15.3%) assigned to rhythm control and in 89 patients (22.0%) to rate control (P=0.0128). No significant differences between the treatment strategies were observed in the incidences of death, stroke, bleeding and heart failure. Meanwhile, significantly fewer patients requested changes of assigned treatment strategy in the rhythm control vs the rate control group, which was accompanied by improvement in AF-specific quality of life scores. Conclusion The J-RHYTHM study showed that rhythm control was associated with fewer primary endpoints than rate control. However, mortality and cardiovascular morbidity were not affected by the treatment strategy (umin-CTR No. C000000106).

キーワード

推奨

(英) Adrenergic beta-Antagonists
(英) Aged
(英) Anti-Arrhythmia Agents
(英) Atrial Fibrillation
(英) Calcium Channel Blockers
(英) Endpoint Determination
(英) Female
(英) Heart Conduction System
(英) Heart Rate
(英) Humans
日本(Japan)
(英) Kaplan-Meier Estimate
(英) Male
(英) Middle Aged
生活の質(quality of life)
(英) Sinoatrial Node

発行所

推奨

社団法人日本循環器学会

誌名

必須

Circulation Journal([社団法人日本循環器学会])

(pISSN: 1346-9843, eISSN: 1347-4820)

ISSN	任意	1346-9843 ISSN: 1346-9843 (pISSN: 1346-9843, eISSN: 1347-4820) Title: Circulation journal : official journal of the Japanese Circulation Society Title(ISO): Circ J Supplier: 社団法人日本循環器学会 Publisher: Japanese Circulation Society (NLM Catalog) (Webcat Plus) (医中誌Web) (J-STAGE) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

必須

頁

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242 248

都市

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年月日

必須

2008年 12月 8日

URL

任意

DOI

任意

10.1253/circj.CJ-08-0608 (→Scopusで検索)

PMID

任意

19060419 (→Scopusで検索)

CRID

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WOS

任意

000262822300010

Scopus

任意

2-s2.0-59449090140

評価値

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被引用数

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指導教員

推奨

備考

任意

(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Multicenter Study
(英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

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