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著作: [村尾 和俊]/Yoshioka Rika/[久保 宜明]/Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease/[The Journal of Dermatology]

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EID
286482
EOID
796021
Map
0
LastModified
2015年9月4日(金) 16:33:41
Operator
大家 隆弘
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TRUE
Censor
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Owner
村尾 和俊
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 村尾 和俊([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.皮膚科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Yoshioka Rika
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 久保 宜明([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.皮膚科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease

副題 任意
要約 任意

(英) Genital Bowen disease (BD) has been linked to the high-risk types of human papillomavirus (HPV) infection. Recently, it has been recognized that HPV also can be associated with extragenital BD. HPV oncoproteins E6 and E7 interfere with the function of p53 and pRb, respectively, leading carcinogenesis. p16(INK4a) overexpression induced by inactivation of pRb is recognized as a surrogate marker for HPV-associated cervical cancer. In this study, we examined the presence of HPV DNA in 142 BD lesions by polymerase chain reaction (PCR), and determined the type of HPV by PCR restriction fragment length polymorphism or direct DNA sequencing. HPV DNA was detected in 66.7% of genital BD and 8.3% of extragenital BD. The types of HPV detected were HPV types 6, 16, 33, 52, 56, 58 and 59. We also investigated the expression of p16(INK4a) , pRb and p53 by immunohistochemistry. Positive expression was detected in 88.6% for p16(INK4a) , 25.2% for pRb, and 63.8% for p53. There was no significant difference in p16(INK4a) and pRb expression between HPV-positive and -negative BD. However, a strong correlation of HPV positivity with p53 negativity was found. A total of 66.7% of HPV-positive BD showed no p53 expression, whereas the corresponding rate was 32.8% of HPV-negative BD. This study demonstrated that HPV can participate in the development of BD, not only in the genital lesion, but also in extragenital lesion. p16(INK) (4a) overexpression is not a marker for HPV infection in BD. Instead, negative p53 expression is correlated with HPV-associated BD.

キーワード 推奨
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誌名 必須 The Journal of Dermatology(日本皮膚科学会)
(pISSN: 0385-2407, eISSN: 1346-8138)
ISSN 任意 1346-8138
ISSN: 0385-2407 (pISSN: 0385-2407, eISSN: 1346-8138)
Title: The Journal of dermatology
Title(ISO): J Dermatol
Supplier: Japanese Dermatological Association
Publisher: Wiley Publishing
 (NLM Catalog  (医中誌Web  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 41
必須 10
必須 878 884
都市 任意
年月日 必須 2014年 10月 初日
URL 任意
DOI 任意 10.1111/1346-8138.12613    (→Scopusで検索)
PMID 任意 25201325    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-84908410065
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1111/1346-8138.12613

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) KeywordList.Keyword: Bowen disease

  5. (英) KeywordList.Keyword: human papillomavirus

  6. (英) KeywordList.Keyword: p16INK4a

  7. (英) KeywordList.Keyword: p53

  8. (英) KeywordList.Keyword: pRb