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著作: Chida Dai/[三好 圭子]/Sato Tsuyoshi/Yoda Tetsuya/Kikusui Takefumi/Iwakura Yoichiro/The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2-deficient mice./[Endocrinology]

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LastModified
2014年10月6日(月) 09:58:44
Operator
三好 圭子
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Chida Dai
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 三好 圭子([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Sato Tsuyoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Yoda Tetsuya
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kikusui Takefumi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Iwakura Yoichiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) The role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in melanocortin receptor 2-deficient mice.

副題 任意
要約 任意

(英) Maternal glucocorticoids are critical for fetal development, but overexpression can be deleterious. Previously we established a mouse line deficient in melanocortin receptor 2 (MC2R). MC2R(-/-) mice have undetectable levels of corticosterone despite high levels of ACTH and defects resembling those in patients with familial glucocorticoid deficiency. Here we analyzed the role of glucocorticoids in pregnancy, parturition, lactation, and nurturing in MC2R(-/-) mice. MC2R(-/-) mice were fertile and produced normal litters when crossed with MC2R(+/+) mice. However, MC2R(-/-) females crossed with MC2R(-/-) males had no live births, and approximately 20% of the embryos at d 18.5 of pregnancy were of normal body size but were dead when born. MC2R(-/-) pregnant females crossed with MC2R(+/+) males had detectable serum corticosterone levels, suggesting the transplacental passage of corticosterone from fetus to mother. MC2R(+/-) pups delivered from MC2R(-/-) females crossed with MC2R(+/+) males mice thrived poorly with MC2R(-/-) mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R(-/-) females are poor mothers or cannot nurse. MC2R(-/-) females had normal alveoli, but penetration of mammary epithelium into fat pads and expression of milk proteins were reduced. Myoepithelial cells, which force milk out of the alveoli, were fully developed and differentiated. Pup retrieval behavior was normal in MC2R(-/-) mice. Exogenous corticosterone rescued expression of milk proteins in MC2R(-/-) mothers, and the pups of treated mothers grew to adulthood. Our results reveal the importance of glucocorticoids for fetal survival late in pregnancy, mammary gland development, and milk protein gene expression.

キーワード 推奨
  1. (英) Animals
  2. (英) Female
  3. (英) Glucocorticoids
  4. (英) Lactation
  5. (英) Male
  6. (英) Mice
  7. (英) Mice, Knockout
  8. (英) Mice, Mutant Strains
  9. (英) Parturition
  10. (英) Polymerase Chain Reaction
  11. (英) Pregnancy
  12. (英) Receptor, Melanocortin, Type 2
  13. (英) Receptors, Glucocorticoid
発行所 推奨
誌名 必須 Endocrinology([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)
ISSN 任意 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 152
必須 4
必須 1652 1660
都市 任意
年月日 必須 2011年 2月 8日
URL 任意
DOI 任意 10.1210/en.2010-0935    (→Scopusで検索)
PMID 任意 21303938    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article

  2. (英) PublicationType: Research Support, Non-U.S. Gov't