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著作: [江西 哲也]/[油形 公則]/[高橋 光彦]/[佐藤 亮祐]/[西良 浩一]/[安井 夏生]/Hypertrophic chondrocytes in the rabbit growth plate can proliferate and differentiate into osteogenic cells when capillary invasion is interposed by a membrane filter./[PLoS ONE]

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EID
285827
EOID
751400
Map
0
LastModified
2014年10月21日(火) 16:28:38
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
西良 浩一
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
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著者 必須
  1. 江西 哲也
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 油形 公則
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 高橋 光彦
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 佐藤 亮祐
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 西良 浩一([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.運動機能外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 安井 夏生
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Hypertrophic chondrocytes in the rabbit growth plate can proliferate and differentiate into osteogenic cells when capillary invasion is interposed by a membrane filter.

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(英) The fate of hypertrophic chondrocytes during endochondral ossification remains controversial. It has long been thought that the calcified cartilage is invaded by blood vessels and that new bone is deposited on the surface of the eroded cartilage by newly arrived cells. The present study was designed to determine whether hypertrophic chondrocytes were destined to die or could survive to participate in new bone formation. In a rabbit experiment, a membrane filter with a pore size of 1 µm was inserted in the middle of the hypertrophic zone of the distal growth plate of ulna. In 33 of 37 animals, vascular invasion was successfully interposed by the membrane filter. During 8 days, the cartilage growth plate was enlarged, making the thickness 3-fold greater than that of the nonoperated control side. Histological examination demonstrated that the hypertrophic zone was exclusively elongated. At the terminal end of the growth plate, hypertrophic chondrocytes extruded from their territorial matrix into the open cavity on the surface of the membrane filter. The progenies of hypertrophic chondrocytes (PHCs) were PCNA positive and caspase-3 negative. In situ hybridization studies demonstrated that PHCs did not express cartilage matrix proteins anymore but expressed bone matrix proteins. Immunohistochemical studies also demonstrated that the new matrix produced by PHCs contained type I collagen, osteonectin, and osteocalcin. Based on these results, we concluded that hypertrophic chondrocytes switched into bone-forming cells after vascular invasion was interposed in the normal growth plate.

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誌名 必須 PLoS ONE(Public Library of Science)
(eISSN: 1932-6203)
ISSN 任意 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 9
必須 8
必須 e104638 e104638
都市 任意
年月日 必須 2014年 8月 14日
URL 任意
DOI 任意 10.1371/journal.pone.0104638    (→Scopusで検索)
PMID 任意 25121501    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1371/journal.pone.0104638

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) OtherID: PMC4133260