徳島大学 教育・研究者情報データベース(EDB)

1. (英) Kawano Takanori

   役割	任意
   貢献度	任意
   学籍番号	推奨

2. (英) Prananingrum Widyasri

   役割	任意
   貢献度	任意
   学籍番号	推奨

3. 石田 雄一([徳島大学.病院.診療科.歯科.そしゃく科(第一補綴科)])

   役割	任意
   貢献度	任意
   学籍番号	推奨

4. 後藤 崇晴([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面補綴学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

5. 内藤 禎人

   役割	任意
   貢献度	任意
   学籍番号	推奨

6. 渡邉 恵([徳島大学.病院.診療科.歯科.そしゃく科(第一補綴科)])

   役割	任意
   貢献度	任意
   学籍番号	推奨

7. 友竹 偉則([徳島大学.病院.中央診療施設等.口腔インプラントセンター])

   役割	任意
   貢献度	任意
   学籍番号	推奨

8. 市川 哲雄([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面補綴学])

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) Blue-violet laser modification of titania treated titanium: antibacterial and osteo-inductive effects

(英) Many studies on surface modifications of titanium have been performed in an attempt to accelerate osseointegration. Recently, anatase titanium dioxide has been found to act as a photocatalyst that expresses antibiotic properties and exhibits hydrophilicity after ultraviolet exposure. A blue-violet semiconductor laser (BV-LD) has been developed as near-ultraviolet light. The purpose of this study was to investigate the effects of exposure to this BV-LD on surface modifications of titanium with the goal of enhancing osteoconductive and antibacterial properties. The surfaces of pure commercial titanium were polished with #800 waterproof polishing papers and were treated with anatase titania solution. Specimens were exposed using BV-LD (λ = 405 nm) or an ultraviolet light-emitting diode (UV-LED, λ = 365 nm) at 6 mW/cm(2) for 3 h. The surface modification was evaluated physically and biologically using the following parameters or tests: surface roughness, surface temperature during exposure, X-ray diffraction (XRD) analysis, contact angle, methylene blue degradation tests, adherence of Porphyromonas gingivalis, osteoblast and fibroblast proliferation, and histological examination after implantation in rats. No significant changes were found in the surface roughness or XRD profiles after exposure. BV-LD exposure did not raise the surface temperature of titanium. The contact angle was significantly decreased, and methylene blue was significantly degraded. The number of attached P. gingivalis organisms was significantly reduced after BV-LD exposure compared to that in the no exposure group. New bone was observed around exposed specimens in the histological evaluation, and both the bone-to-specimen contact ratio and the new bone area increased significantly in exposed groups. This study suggested that exposure of titanium to BV-LD can enhance the osteoconductivity of the titanium surface and induce antibacterial properties, similar to the properties observed following exposure to UV-LED.

1. (英) Article.ELocationID: 10.1371/journal.pone.0084327

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) OtherID: PMC3866166