徳島大学 教育・研究者情報データベース(EDB)

1. (日) 柏木 圭介

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2. 橋本 一郎([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.形成外科学])

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(英) Quantitative analysis of hemodynamics of congested island flaps under leech therapy

(英) A congested flap is a good indication for leech therapy. However, determining the appropriate number of leeches as well as the appropriate application time in clinical cases is difficult. We analyzed hemodynamics in rabbit island flaps under leech therapy to find a suitable clinical procedure for determining the appropriate number of leeches to be used and the duration of therapy. Island flaps were raised in 35 rabbit ears, and congestion was induced by venous clamping. Treatment involved use of 1 or 3 leeches and was begun 60 minutes after venous occlusion. Flaps were examined for area of surviving tissue, alterations in transcutaneous oxygen and carbon dioxide tension (TcPO2 and TcPCO2), and flow volume. Arteriole and venule diameters and flow velocities were examined microscopically. Flap survival area in the 3-leech therapy group was significantly larger than the 1-leech therapy group and the control group. With 3-leech therapy, TcPCO2 decreased significantly, as did arteriole and venule diameters. After clamp release, TcPCO2 and venule diameter continued to decrease in this group, and flow velocity increased significantly. Leech therapy may salvage compromised flaps by replacing congested blood with new arterial blood and thus maintaining flap viability. TcPO2 and TcPCO2 monitoring may help evaluate the therapeutic effect and determine the appropriate number of leeches to apply and the duration of therapy.

1. (英) Animals
2. (英) Arterioles
3. (英) Carbon Dioxide
4. (英) Free Tissue Flaps
5. (英) Hemodynamics
6. (英) Leeching
7. (英) Microcirculation
8. (英) Oxygen
9. (英) Rabbits
10. (英) Venules

1. (英) Article.PublicationTypeList.PublicationType: Journal Article