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著作: 柏木 圭介/[橋本 一郎]/Quantitative analysis of hemodynamics of congested island flaps under leech therapy/[The Journal of Medical Investigation : JMI]

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283569
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2017年12月4日(月) 14:01:57
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橋本 一郎
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (日) 柏木 圭介
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 橋本 一郎([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.形成外科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Quantitative analysis of hemodynamics of congested island flaps under leech therapy

副題 任意
要約 任意

(英) A congested flap is a good indication for leech therapy. However, determining the appropriate number of leeches as well as the appropriate application time in clinical cases is difficult. We analyzed hemodynamics in rabbit island flaps under leech therapy to find a suitable clinical procedure for determining the appropriate number of leeches to be used and the duration of therapy. Island flaps were raised in 35 rabbit ears, and congestion was induced by venous clamping. Treatment involved use of 1 or 3 leeches and was begun 60 minutes after venous occlusion. Flaps were examined for area of surviving tissue, alterations in transcutaneous oxygen and carbon dioxide tension (TcPO2 and TcPCO2), and flow volume. Arteriole and venule diameters and flow velocities were examined microscopically. Flap survival area in the 3-leech therapy group was significantly larger than the 1-leech therapy group and the control group. With 3-leech therapy, TcPCO2 decreased significantly, as did arteriole and venule diameters. After clamp release, TcPCO2 and venule diameter continued to decrease in this group, and flow velocity increased significantly. Leech therapy may salvage compromised flaps by replacing congested blood with new arterial blood and thus maintaining flap viability. TcPO2 and TcPCO2 monitoring may help evaluate the therapeutic effect and determine the appropriate number of leeches to apply and the duration of therapy.

キーワード 推奨
  1. (英) Animals
  2. (英) Arterioles
  3. (英) Carbon Dioxide
  4. (英) Free Tissue Flaps
  5. (英) Hemodynamics
  6. (英) Leeching
  7. (英) Microcirculation
  8. (英) Oxygen
  9. (英) Rabbits
  10. (英) Venules
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 60
必須 3,4
必須 213 220
都市 任意
年月日 必須 2013年 0月 初日
URL 任意
DOI 任意 10.2152/jmi.60.213    (→Scopusで検索)
PMID 任意 24190038    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意 2-s2.0-84887011872
機関リポジトリ 106359
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article