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著作: Tani Anna/[安井 敏之]/Matsui Sumika/Kato Takeshi/Kunimi Kotaro/Tsuchiya Naoko/Yuzurihara Mitsutoshi/Kase Yoshio/Irahara Minoru/Different circulating levels of monocyte chemoattractant protein-1 and interleukin-8 during the menopausal transition./[Cytokine]

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EID
281605
EOID
810294
Map
0
LastModified
2016年2月29日(月) 13:13:06
Operator
三好 小文
Avail
TRUE
Censor
0
Owner
安井 敏之
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種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Tani Anna
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 安井 敏之([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.生殖・更年期医療学]/[徳島大学.医学部.保健学科.看護学専攻.母性·小児看護学講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Matsui Sumika
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kato Takeshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kunimi Kotaro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Tsuchiya Naoko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Yuzurihara Mitsutoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Kase Yoshio
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Irahara Minoru
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Different circulating levels of monocyte chemoattractant protein-1 and interleukin-8 during the menopausal transition.

副題 任意
要約 任意

(英) The aim of the present study was to clarify the changes in circulating cytokines and chemokines in women during the menopausal transition by using a detailed classification. A total of 554 women were recruited for this study from the outpatient clinic of the Department of Obstetrics and Gynecology, Tokushima University Hospital. We divided the women into seven stages by menstrual regularity and FSH level: mid-reproductive stage, late reproductive stage, early menopausal transition, late menopausal transition, very early postmenopause, early postmenopause and late postmenopause. We measured serum concentrations of nine cytokines (IL-1β, IL-5, IL-6, IL-7, IL-8, IL-10, TNF-α, MIP-1β and MCP-1). Serum IL-8 concentrations in postmenopausal women were significantly (p = 0.001) higher than those in women in the mid- or late reproductive stage and women in early or late menopausal transition. Serum MCP-1 levels in women in late menopausal transition and postmenopause were significantly (p < 0.001) higher than those in women in the mid- or late reproductive stage and women in early menopausal transition. MCP-1 level showed a significant positive correlation (r = 0.215, p < 0.01) with FSH level in women in menopausal transition. By using a detailed classification of menopausal transition, patterns of changes in IL-8 and MCP-1 levels during the menopausal transition were found to be different. IL-8 level showed a high level after menopause, while MCP-1 level showed a high level in menopausal transition. MCP-1 may be sensitive to hormonal change and may be involved in the development of estrogen deficiency diseases.

キーワード 推奨
  1. (英) Adult
  2. (英) Aged
  3. (英) Chemokine CCL2
  4. (英) Chemokines
  5. (英) Estradiol
  6. (英) Female
  7. (英) Follicle Stimulating Hormone
  8. (英) Humans
  9. (英) Interleukin-8
  10. (英) Luteinizing Hormone
  11. (英) Menopause
  12. (英) Middle Aged
発行所 推奨
誌名 必須 Cytokine(International Cytokine Society)
(pISSN: 1043-4666, eISSN: 1096-0023)
ISSN 任意 1096-0023
ISSN: 1043-4666 (pISSN: 1043-4666, eISSN: 1096-0023)
Title: Cytokine
Title(ISO): Cytokine
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 62
必須 1
必須 86 90
都市 任意
年月日 必須 2013年 3月 11日
URL 任意
DOI 任意 10.1016/j.cyto.2013.02.011    (→Scopusで検索)
PMID 任意 23490412    (→Scopusで検索)
NAID 任意
WOS 任意 000317795000014
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1016/j.cyto.2013.02.011

  2. (英) Article.ELocationID: S1043-4666(13)00064-1

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't