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著作: [森 達夫]/[森 健治]/Suzue Masashi/[伊藤 弘道]/[香美 祥二]/Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus/[Brain & Development]

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EID
280470
EOID
801661
Map
0
LastModified
2015年11月9日(月) 11:10:34
Operator
三木 ちひろ
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TRUE
Censor
0
Owner
香美 祥二
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 森 達夫([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.小児科学]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 森 健治([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.子どもの保健・看護学]/[徳島大学.医学部.保健学科.看護学専攻.母性·小児看護学講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Suzue Masashi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 伊藤 弘道
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 香美 祥二([徳島大学.病院])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus

副題 任意
要約 任意

(英) Over the past several years, tacrolimus has attracted attention as a new therapeutic drug for myasthenia gravis (MG), but few reports have considered its use for MG in pediatric patients, and most of these have focused on severe systemic MG. In this case report, we used tacrolimus to successfully treat a 13-year-old boy with ocular MG who had suffered from severe steroid complications, including a failure of thrive and osteoporosis. He first showed symptoms of ocular MG at age 2 years 3 months. At age 13 years, he was receiving PSL (3.75 mg/day), but the symptoms of ocular MG recurred. We increased the dosage of oral PSL up to 30 mg/day, and three courses of mPSL pulse therapy were applied, but these therapies had only limited effect, and his symptoms worsened. Tacrolimus was started at 0.4 mg/day (0.011 mg/kg/day), and every 2 weeks the dose was gradually increased by 0.2 mg/day. His symptoms of MG began to improve 3 weeks after the initial administration of tacrolimus. Approximately 3 months after the start of tacrolimus administration, PSL was discontinued. Currently, at 1 year and 4 months after the start of tacrolimus administration, while slight ptosis is observed in the evening, it does not influence his daily life, and his condition remains comparable to that when he stopped taking PSL. No adverse effects of tacrolimus have been recognized. In pediatric patients with steroid-dependent ocular MG without thymectomy, tacrolimus may be a safe and effective alternative to steroid and thymectomy.

キーワード 推奨
  1. (英) Adolescent
  2. (英) Body Weight
  3. (英) Developmental Disabilities
  4. (英) Follow-Up Studies
  5. (英) Humans
  6. (英) Immunosuppressive Agents
  7. (英) Male
  8. (英) Myasthenia Gravis
  9. (英) Tacrolimus
発行所 推奨
誌名 必須 Brain & Development(日本小児神経学会)
(pISSN: 0387-7604, eISSN: 1872-7131)
ISSN 任意 1872-7131
ISSN: 0387-7604 (pISSN: 0387-7604, eISSN: 1872-7131)
Title: Brain & development
Title(ISO): Brain Dev
Publisher: Elsevier BV
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 35
必須 5
必須 445 448
都市 任意
年月日 必須 2013年 5月 初日
URL 任意
DOI 任意 10.1016/j.braindev.2012.06.012    (→Scopusで検索)
PMID 任意 22840813    (→Scopusで検索)
NAID 任意
WOS 任意 000318390700011
Scopus 任意 2-s2.0-84875894491
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1016/j.braindev.2012.06.012

  2. (英) Article.ELocationID: S0387-7604(12)00162-3

  3. (英) Article.PublicationTypeList.PublicationType: Case Reports

  4. (英) Article.PublicationTypeList.PublicationType: Journal Article