著作: [武知 浩和]/[馬渡 一諭]/[原田 永勝]/[中屋 豊]/Asakura Megumi/[粟飯原 睦美]/[滝沢 宏光]/[後藤 正和]/Nishino Takeshi/Minato Takuya/[古北 由仁]/[山本 洋太]/Yuasa Yasuhiro/Yamai Hiromichi/[吉田 卓弘]/[清家 純一]/[丹黒 章]/Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model./[The Journal of Medical Investigation : JMI]
(英) Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model.
(英) Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20 mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO(®)) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.
|発行所||推奨||(英) The University of Tokushima Faculty of Medicine|
The Journal of Medical Investigation : JMI([徳島大学.医学部])
|年月日||必須||2014年 0月 初日|