279321: [中本真理子]/[有澤孝吉]/[上村浩一]/[勝浦-釜野桜子]/Takami Hidenobu/Sawachika Fusakazu/[山口美輪]/Juta Tomoya/[酒井徹]/Toda Eisaku/Mori Kei/Hasegawa Manabu/Tanto Masaharu/Shima Masayuki/Sumiyoshi Yoshio/Morinaga Kenji/Kodama Kazunori/Suzuki Takaichiro/Nagai Masaki/Satoh Hiroshi/Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population./[International Archives of Occupational and Environmental Health]

著作: [中本真理子]/[有澤孝吉]/[上村浩一]/[勝浦-釜野桜子]/Takami Hidenobu/Sawachika Fusakazu/[山口美輪]/Juta Tomoya/[酒井徹]/Toda Eisaku/Mori Kei/Hasegawa Manabu/Tanto Masaharu/Shima Masayuki/Sumiyoshi Yoshio/Morinaga Kenji/Kodama Kazunori/Suzuki Takaichiro/Nagai Masaki/Satoh Hiroshi/Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population./[International Archives of Occupational and Environmental Health]

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EID: 279321
EOID: 1002446
Map: 0
LastModified: 2021年3月16日(火) 07:59:40
Operator: 有澤孝吉
Avail: TRUE
Censor: 0
Owner: 上村浩一
Read: 継承
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Delete: 継承

種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

博士後期課程学生による研究報告

組織

推奨

著者

必須

中本真理子([徳島大学.大学院医歯薬学研究部.医学域.先端栄養学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.実践栄養学])

役割任意

貢献度任意

学籍番号推奨
有澤孝吉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.予防医学])

役割任意

貢献度任意

学籍番号推奨
上村浩一

役割任意

貢献度任意

学籍番号推奨
勝浦-釜野桜子([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.社会環境衛生学講座.予防医学]/->個人[釜野桜子])

役割任意

貢献度任意

学籍番号推奨
(英) Takami Hidenobu

役割任意

貢献度任意

学籍番号推奨
(英) Sawachika Fusakazu

役割任意

貢献度任意

学籍番号推奨
山口美輪

役割任意

貢献度任意

学籍番号推奨
(英) Juta Tomoya

役割任意

貢献度任意

学籍番号推奨
酒井徹([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.実践栄養学])

役割任意

貢献度任意

学籍番号推奨
(英) Toda Eisaku

役割任意

貢献度任意

学籍番号推奨
(英) Mori Kei

役割任意

貢献度任意

学籍番号推奨
(英) Hasegawa Manabu

役割任意

貢献度任意

学籍番号推奨
(英) Tanto Masaharu

役割任意

貢献度任意

学籍番号推奨
(英) Shima Masayuki

役割任意

貢献度任意

学籍番号推奨
(英) Sumiyoshi Yoshio

役割任意

貢献度任意

学籍番号推奨
(英) Morinaga Kenji

役割任意

貢献度任意

学籍番号推奨
(英) Kodama Kazunori

役割任意

貢献度任意

学籍番号推奨
(英) Suzuki Takaichiro

役割任意

貢献度任意

学籍番号推奨
(英) Nagai Masaki

役割任意

貢献度任意

学籍番号推奨
(英) Satoh Hiroshi

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population.

副題

任意

要約

任意

(英) Previous studies reported that exposure to dioxins was associated with an increased risk of various diseases in general populations. The aim of this study was to examine the association between levels of dioxins in blood and allergic and other diseases. We conducted a cross-sectional study on 1,063 men and 1,201 women (aged 15-76 years), who were living throughout Japan and not occupationally exposed to dioxins, during 2002-2010. In fasting blood samples, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) were analyzed by isotope dilution high-resolution gas chromatography/mass spectrometry. We obtained information on life style and self-reported history of diseases using a questionnaire. Blood pressure, blood levels of hemoglobin A1c, and serum lipids were also measured. Multiple logistic regression models were used to analyze the association between dioxin levels in blood and various diseases. Toxic equivalents of PCDDs/PCDFs and total dioxins showed significant inverse dose-response relationships with atopic dermatitis, after adjustments for potential confounders. The highest quartile for total dioxins had an adjusted odds ratio of 0.26 (95 % confidence interval 0.08-0.70) compared to the reference group (first quartile). The odds ratios for hypertension, diabetes mellitus, hyperlipidemia, gout in men, and gynecologic diseases in women significantly increased with increasing toxic equivalents of PCDDs/PCDFs, DL-PCBs, and total dioxins in blood. The present findings suggest that background exposure to dioxins was associated with reduced risk of atopic dermatitis. The results also support the idea that low-level exposure to dioxins is associated with an increased risk of diabetes, hypertension, and hyperlipidemia.

キーワード

推奨

(英) Adolescent
(英) Adult
(英) Aged
(英) Benzofurans
(英) Cross-Sectional Studies
(英) Dermatitis, Atopic
(英) Diabetes Mellitus
(英) Environmental Exposure
(英) Female
(英) Humans
(英) Hyperlipidemias
(英) Hypertension
(英) Japan
(英) Life Style
(英) Male
(英) Middle Aged
(英) Polychlorinated Biphenyls
(英) Questionnaires
(英) Tetrachlorodibenzodioxin
(英) Young Adult

発行所

推奨

誌名

必須

International Archives of Occupational and Environmental Health([Springer-Verlag])

(pISSN: 0340-0131, eISSN: 1432-1246)

ISSN	任意	1432-1246 ISSN: 0340-0131 (pISSN: 0340-0131, eISSN: 1432-1246) Title: International archives of occupational and environmental health Title(ISO): Int Arch Occup Environ Health Supplier: Springer Online Journal Archive Publisher: Springer (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

必須

頁

必須

849 859

都市

任意

年月日

必須

2013年 11月初日

URL

任意

DOI

任意

10.1007/s00420-012-0819-8 (→Scopusで検索)

PMID

任意

23014754 (→Scopusで検索)

CRID

任意

WOS

任意

Scopus

任意

評価値

任意

被引用数

任意

指導教員

推奨

備考

任意

(英) Article.ELocationID: 10.1007/s00420-012-0819-8
(英) Article.PublicationTypeList.PublicationType: Journal Article

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University