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著作: Kitayama Hiroki/Takechi Yuki/[玉井 伸岳]/[松木 均]/Yomota Chikako/[斎藤 博幸]/Thermotropic phase behavior of hydrogenated soybean phosphatidylcholine-cholesterol binary liposome membrane./[Chemical & Pharmaceutical Bulletin]

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EID
278952
EOID
1041277
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2022年5月5日(木) 21:05:20
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玉井 伸岳
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kitayama Hiroki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Takechi Yuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 玉井 伸岳([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 松木 均([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yomota Chikako
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 斎藤 博幸
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Thermotropic phase behavior of hydrogenated soybean phosphatidylcholine-cholesterol binary liposome membrane.

副題 任意
要約 任意

(英) By combination of differential scanning calorimetry (DSC) and fluorescence spectroscopy of 6-propionyl-2-(dimethylamino)naphthalene (Prodan), we elucidated the thermotropic phase behavior of hydrogenated soybean phosphatidylcholine (HSPC)-cholesterol binary liposome membrane which has similar lipid composition to Doxil®, the widely used liposome product in treatment of various tumors. We found that the characteristic points at cholesterol mole fraction (Xch)=0.023 and 0.077 correspond to the hexagonal lattice, in which cholesterol molecules are considered to be regularly distributed in all regions of HSPC lipid bilayer with 1 : 42 and 1 : 12 units, respectively, as static averaged structures. Apparent endothermic peak disappeared at Xch=0.40 in the DSC thermograms, indicating the existence of single liquid ordered phase at Xch>0.40. In addition, fluorescence measurements of Prodan and its lauroyl derivative in poly(ethylene glycol) (PEG)-modified liposomes indicated that PEG modification has a negligible effect on the phase behavior of HSPC-cholesterol binary liposome membrane. These results may provide useful information in developing novel liposome products whose stability and encapsulated drug release are controlled.

(日) By combination of differential scanning calorimetry (DSC) and fluorescence spectroscopy of 6-propionyl-2-(dimethylamino)naphthalene (Prodan), we elucidated the thermotropic phase behavior of hydrogenated soybean phosphatidylcholine (HSPC)-cholesterol binary liposome membrane which has similar lipid composition to Doxil®, the widely used liposome product in treatment of various tumors. We found that the characteristic points at cholesterol mole fraction (Xch)=0.023 and 0.077 correspond to the hexagonal lattice, in which cholesterol molecules are considered to be regularly distributed in all regions of HSPC lipid bilayer with 1 : 42 and 1 : 12 units, respectively, as static averaged structures. Apparent endothermic peak disappeared at Xch=0.40 in the DSC thermograms, indicating the existence of single liquid ordered phase at Xch>0.40. In addition, fluorescence measurements of Prodan and its lauroyl derivative in poly(ethylene glycol) (PEG)-modified liposomes indicated that PEG modification has a negligible effect on the phase behavior of HSPC-cholesterol binary liposome membrane. These results may provide useful information in developing novel liposome products whose stability and encapsulated drug release are controlled.

キーワード 推奨
  1. (英) liposome
  2. (英) cholesterol
  3. (英) phase diagram
  4. (英) differential scanning calorimetry
  5. (英) Prodan
発行所 推奨 (英) The Pharmaceutical Society of Japan
誌名 必須 Chemical & Pharmaceutical Bulletin([日本薬学会])
(pISSN: 0009-2363, eISSN: 1347-5223)
ISSN 任意 1347-5223
ISSN: 0009-2363 (pISSN: 0009-2363, eISSN: 1347-5223)
Title: Chemical & pharmaceutical bulletin
Title(ISO): Chem Pharm Bull (Tokyo)
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 62
必須 1
必須 58 63
都市 任意
年月日 必須 2014年 0月 初日
URL 任意 http://ci.nii.ac.jp/naid/130003381805/
DOI 任意 10.1248/cpb.c13-00587    (→Scopusで検索)
PMID 任意 24390493    (→Scopusで検索)
CRID 任意 1390282679153790464
NAID 130003381805
WOS 任意 000329002300008
Scopus 任意 2-s2.0-84892158447
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article

  2. (英) PublicationType: Research Support, Non-U.S. Gov't