徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.分子口腔医学講座.口腔分子病態学(2004年4月1日〜2015年3月31日)
2. 徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面補綴学(2004年4月1日〜2015年3月31日)

1. (英) Meinar Nur Ashrin

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2. 新垣 理恵子

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3. 山田 安希子

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4. (英) Kondo Tomoyuki / (日) 近藤 智之 / (読) こんどう ともゆき

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5. (英) Kurosawa Mie / (日) 黒澤 実愛

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6. 工藤 保誠([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])

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7. 渡邉 恵([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面補綴学]/[徳島大学.病院.診療科.歯科.そしゃく科(第一補綴科)])

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8. 市川 哲雄

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9. 林 良夫

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10. 石丸 直澄

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(英) A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice.

(英) Ni is the most frequent cause of contact allergy induced by metals. However, the underlying mechanism of this induction is unknown. Our previous research demonstrates that activation of dendritic cells (DCs) through p38MAPK/MKK6 is required for Ni-induced allergy in mice. In the current study, we investigated the cellular and molecular mechanisms underlying Ni-induced allergy using a mouse model that involves injecting Ni into the ear, with or without Freund's incomplete or complete adjuvants. Nickel had greater potential to cause allergic reactions compared with palladium and gold. Among the proteins expressed at higher levels in mice with Ni-induced allergy, we focused on thymic stromal lymphopoietin (TSLP), which is produced in abundance by keratinocytes. We detected increased expression of the TSLP receptor (TSLPR) in DCs from cervical lymph nodes of mice with Ni-induced allergy, suggesting that DCs in ear tissues were activated through TSLPR signaling induced by keratinocyte-derived TSLP. Furthermore, delayed-type hypersensitivity reactions in mice with Ni-induced allergy were decreased significantly by injection of a Tslp-short interfering RNA along with atelocollagen in the ear skin. These results suggest that Ni allergy may be triggered by a TSLP/TSLPR-mediated interaction between epithelial and immune cells.

1. (英) Animals
2. (英) Blotting, Western
3. (英) Cytokines
4. (英) Dendritic Cells
5. (英) Disease Models, Animal
6. (英) Enzyme-Linked Immunosorbent Assay
7. (英) Female
8. (英) Flow Cytometry
9. (英) Hypersensitivity
10. (英) Immunoglobulins
11. 免疫組織化学(immunohistochemistry)
12. (英) Mice
13. (英) Mice, Inbred C57BL
14. (英) Nickel
15. (英) Oligonucleotide Array Sequence Analysis
16. (英) RNA, Small Interfering
17. (英) Real-Time Polymerase Chain Reaction
18. (英) Receptors, Cytokine
19. (英) Reverse Transcriptase Polymerase Chain Reaction

1. (英) Article.ELocationID: 10.4049/jimmunol.1300276

2. (英) Article.DataBankList.DataBank.DataBankName: GEO

3. (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: GSE52466

4. (英) Article.PublicationTypeList.PublicationType: Journal Article

5. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

6. (英) OtherID: PMC3993049