278543: [釜野桜子]/[上村浩一]/[有澤孝吉]/[山口美輪]/Nobuyuki Hamajima/Kenji Wakai/Rieko Okada/Sadao Suzuki/Naoto Taguchi/Yoshikuni Kita/Keizo Ohnaka/Tara Sefanya Kairupan/Daisuke Matsui/Isao Oze/Haruo Mikami/Michiaki Kubo/Hideo Tanaka/A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study/[Endocrine]

著作: [釜野桜子]/[上村浩一]/[有澤孝吉]/[山口美輪]/Nobuyuki Hamajima/Kenji Wakai/Rieko Okada/Sadao Suzuki/Naoto Taguchi/Yoshikuni Kita/Keizo Ohnaka/Tara Sefanya Kairupan/Daisuke Matsui/Isao Oze/Haruo Mikami/Michiaki Kubo/Hideo Tanaka/A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study/[Endocrine]

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EID: 278543
EOID: 876637
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種別

必須

学術論文(審査論文)

言語

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英語

招待

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審査

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カテゴリ

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研究

共著種別

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学究種別

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組織

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著者

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釜野桜子([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.予防医学]/->個人[勝浦桜子])

役割任意

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学籍番号推奨
上村浩一

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学籍番号推奨
有澤孝吉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.予防医学])

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学籍番号推奨
山口美輪

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貢献度任意

学籍番号推奨
(英) Nobuyuki Hamajima

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(英) Kenji Wakai

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(英) Rieko Okada

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(英) Sadao Suzuki

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(英) Naoto Taguchi

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貢献度任意

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(英) Yoshikuni Kita

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貢献度任意

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(英) Keizo Ohnaka

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貢献度任意

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(英) Tara Sefanya Kairupan

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(英) Daisuke Matsui

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(英) Isao Oze

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(英) Haruo Mikami

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(英) Michiaki Kubo

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(英) Hideo Tanaka

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貢献度任意

学籍番号推奨

題名

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(英) A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study

副題

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要約

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(英) Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-69 years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20 years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend = 0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend = 0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result.

キーワード

推奨

(英) Adult
(英) Aged
(英) Asian Continental Ancestry Group
(英) Body Mass Index
(英) Female
(英) Genetic Association Studies
(英) Genetic Loci
(英) Humans
(英) Japan
(英) Lipid Metabolism
(英) Male
(英) Middle Aged
(英) Multicenter Studies as Topic
(英) Polymorphism, Single Nucleotide
(英) Receptor, Melanocortin, Type 4
(英) Triglycerides

発行所

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誌名

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Endocrine([Springer])

(pISSN: 1355-008X, eISSN: 1559-0100)

ISSN	任意	1355-008X ISSN: 1355-008X (pISSN: 1355-008X, eISSN: 1559-0100) Title: Endocrine Title(ISO): Endocrine Supplier: Springer Online Journal Archive Publisher: Springer (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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81 89

都市

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年月日

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2014年 6月 1日

URL

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DOI

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10.1007/s12020-014-0306-y (→Scopusで検索)

PMID

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24880622 (→Scopusで検索)

CRID

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WOS

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000344087600011

Scopus

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2-s2.0-84906935301

評価値

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被引用数

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指導教員

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備考

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(英) Article.ELocationID: 10.1007/s12020-014-0306-y
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University